Preserving the Precious Gift of Sight

Helmerich Chair

Walter H. Helmerich Research Chair

Associate Director, McPherson Eye Research Institute

Kevin W Eliceiri, PhD

Biomedical Engineering

University of Wisconsin

Madison, WI

 

Helmerich Chair 2012 – 2017

Akihiro Ikeda, DVM, PhD
Akihiro Ikeda, DVM, PhD

Medical Genetics

University of Wisconsin

Madison, WI

 

Dr. Ikeda’s Research Project

Identification of Genetic Factors Affecting Aging of the Retina

Current Research Interests

Dr. Ikeda uses mouse models to study the genetic and molecular mechanisms of aging.  His laboratory studies a mouse mutant showing similar symptoms as observed in age-related macular degeneration (AMD) patients. He has identified the mutation in the gene (Tmem135) associated with mitochondria functions and confirmed that the mutation is indeed causing the AMD-like symptoms.

Another major project is to identify genes that determine the severity of aging symptoms in the retina including neurodegeneration, synaptic abnormality, and inflammation using two mouse strains, one of which shows retinal aging symptoms earlier than the other. He has found that a mutation in the bloom syndrome gene (Blm) gene involved in DNA damage repair is responsible for the early-onset of aging symptoms and that Blm may have a role in the mitochondrial function.

The retina of a mutant mouse with accelerated aging symptoms show AMD-like phenotypes such as accumulation of autofluorescence and inflammation.
 

Specifically, Dr. Ikeda’s laboratory aims to identify gene mutations that lead to early onset of aging phenotypes in the mouse retina.  His laboratory also aims to identify genes that cause the difference in the severity of age-dependent retinal abnormalities observed between two mouse inbred strains.  Dr. Ikeda hopes that identification of these genes will allow him to elucidate the molecular mechanisms causing the age-dependent retinal abnormalities, and therefore, enhance our understanding of age-dependent retinal diseases and aging of the retina.

Ikeda Lab
Ikeda Lab
Print Friendly, PDF & Email


Change Font Size

Mission of RRF

The mission of the Retina Research Foundation is to reduce retinal blindness worldwide by funding programs in research and education. As a public charity, RRF raises funds from the private sector and the investment of its endowment funds.

RRF’s 48th Anniversary

October 1, 2017