Preserving the Precious Gift of Sight

Publications

2016 Publications by RRF Grant Recipients

  1. Cowan CS, Sabharwal J, Wu SM. (2016) Space-time codependence of retinal ganglion cells can be explained by novel and separable components of their receptive fields. Physiol Rep. 2016 Sep; 4(17). pii: e12952.
  1. van der Heijden ME, Shah P, Cowan CS, Yang Z, Wu SM, Frankfort BJ. Effects of Chronic and Acute Intraocular Pressure Elevation on Scotopic and Phototopic Contrast Sensitivity in Mice. Invest Ophthalmol Vis Sci. 2016 Jun 1; 57(7):3077-87.
  1. He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG. (2016) Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Report. 2016 Jun 1; 6:26978.
  1. Want J, Jacoby R, Wu SM. (2016) Physiological and morphological characterization of ganglion cells in the salamander retina. Vision Res. 2016 Feb; 119:60-72.
  1. Cowan CS, Abd-El-Barr M, van der Heijden M, Lo EM, Paul D, Bramblett DE, Lem J, Simons DL, Wu SM. (2016) Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. Vision Res. Feb; 119:99-109.
  1. Soens ZT, Li Y, Zhao L, Eblimit A, Dharmat R, Li Y, Chen Y, Naqeeb M, Fajardo N, Lopez I, Sun Z, Koenekoop RK, Chen R. Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Genetics in medicine. 2016 Jan 28;PMID:26820066 PMCID: PMC4965339.
  1. Fu Q, Xu M, Chen X, Sheng X, Yuan Z, Liu Y, Li H, Sun Z, Li H, Yang L, Wang K, Zhang F, Li Y, Zhao C, Sui R, Chen R. CEP78 is mutates in a distinct type of Usher syndrome. J Med Genet. 2016 Sept 14. pii: jmedgenet-2016-104166. doi: 10.1136/jmedgenet-2016-104166. [Epub ahead of print] PMID: 27627988, PMCID: Pending.
  1. Kuang, S.Q., O. Medina-Martinez, D. C. Guo, L. Gong, E.S. Regalado, C.L. Reynolds, C. Boileau, G. Jondeau, S. K. Prakash, C.S. Kwartler, L. Y. Zhu, A.M. Peters, X.Y. Duan, GenTAC Investigators, National Heart, Lung and Blod Institute Go Exome Sequencing Project, M. J. Bamshad, J. Shendure, D.A. Nickerson, R.L. Santos-Cortez, X.R. Dong, S.M. Leal, M. W. Majesky, E.C. Swindell, Jamrich, M., Milewicz, D.M. (2016). FOXE3 Mutations Predispose to Thoracic Aortic Aneurysms and Dissections; Foxe3 Deficiency in Mice Leads to Smooth Muscle Apoptosis and Aortic Rupture. J. Clin Invest. 126(3):948-61. PMID: 26854927.
  1. Gersztenkorn D, Coletta C, Zhu S, Ha Y, Liu H, Tie H, Zhou J, Szabo C, Zhang W, Motamedi M. Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3002-9. doi: 10.1167/iovs.15-18555.
  1. Hein TW, Xu W, Xu X, Kuo L. Acute and chronic hyperglycemia elicit JIP1?JNK-mediated endothelial vasodilator dysfunction of retinal arterioles. Invest Ophthalmol Vis Sci 57(10):4333-4340, 2016.
  1. Sauter MM, Brandt CR. Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis, Experimental Eye Research. 148 (2016) 12-23.
  1. Lee B, Sun W, Lee H, Basavarajappa HD, Sulaiman RS, Sishtla K, Fei X, Corson TW, Seo SY. 2016. Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids. Bioorganic & Medicinal Chemistry Letters, 26, 4277-4281. (appended).
  1. Lee H, Yuan Y, Rhee I, Corson TW, Seo SY. 2016. Synthesis of natural homoisoflavonoids having either 5,7-dihydroxy-6-methoxy or 7-hydroxy-5,6-dimethoxy groups. Molecules, 21, 1058. (appended).
  1. Sulaiman RS, Merrigan S, Quigley J, Boulton ME, Kennedy B, Seo SY, Corson TW. 2016. A small molecule pharmacotherapy ameliorates ocular neovascularization without toxicity. Scientific Reports, 6, 25509. (appended).
  1. Hanke-Gogokhia C, Wu Z, Gerstner CD, Frederick JM, Zhang H, Baehr W (2016). Arf-like protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors. J Biol Chem, 291, 7142-7155. PMID: 26814127. PMCID: PMC4807295.
  1. Rao KN, Zhang W, Li L1, Ronquillo C, Li T, Baehr W, and Khanna H (2016). Ciliopathy-associated protein CEP290 modified the severity of retinal degeneration due to loss of RPGR. Hum Mol Genet. 2016 Mar 2. pii: ddw075. [Epub ahead of print]. PMID:26936822.
  1. Ronquillo CC, Hanke-Gorokhia C, Revelo PM, Frederick JM, Li Jiang, Baehr W (2016). The Nphp5-/- mouse: a model for Leber Congenital Amaurosis. FASEB J. 2016 Jun 21. pii: fj.201600511R. [Epub ahead of print]

2015 Publications by RRF Grant Recipients

775. Eblimiti, A., Xu, H., Nguyen, T.T., Chen, Y., Esteve-Ruud, J., Zhong, H., Lettebore, S., van Reeuwijk, J., Simons, D.L., Ding, Q., Wu, K.M., Li, Y., van Beersum, S., Y., Xu, H., Pickard, P., Wang, K., Gan, L., Wu S.M., Williams, D.S., Mardon, G., Roepman, R., and Chen, R. (2014) Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina. Human Molecular Genetics, 11, 1-18.

776. Khan, A.K., Tse, D.Y., van der Heijden, M., Shah, P., Nusbaum, D., Yang, Z., Wu S.M., and Frankfort, B.J. (2015) Prolonged elevation of intraocular pressure results in retinal ganglion cell loss and abnormal retinal function in mice. Experimental Eye Research, 130, 29-37.

777. Pang, J.J., Frankfort, B.J., Gross, R.L. and Wu, S.M. (2015) Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice. Proc. Nat. Acad. Scien. (USA), 112, 8, 2593-2598.

778. Nusbaum, D.M., Wu, S.M., Frankfort, B.J. (2015) Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice. Experimental Eye Research, 136, 38-44.

779. W.H. Xiong, J.J. Pang, M.E. Pennesi, M. Tekmen, R.M. Duvoisin, S.M. Wu, C. W. Morgans (2015) The effect of PKCα on the light response of rod bipolar cells in the mouse retina. Invest. Ophthalmol. Vis. Sci., 56(8): 4961-4974.

780. Hui Wang, Xia Wang, Xuan Zou, Shan Xu, Hui Li, Keqing Wang, Yumei Li, Fangtian Dong, Rui Chen, Ruifang Sui. Comprehensive molecular diagnosis of a large Chinese Leber congenital amaurosis cohort, IOVS, June 2015, Vol. 56, 3642-3655.

781. Xu M, Gelowani V, Eblimit A, Wang F, Young MP, Sawyer BL, Zhao L, Jenkins G, Creel DJ, Wang K, Ge Z, Wang H, Li Y, Hartnett ME, Chen R. ATF6 is Mutated in Early Onset Photoreceptor Degeneration with Macular Involvement, Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3889-95. doi: 10.1167/iovs.15-16778.

782. Xu, M, Yang L, Wang F, Li H, Wang X, Wang W, Ge Z, Wang K, Zhao L, Li H, Li Y, Sui R, Chen R. Mutations in human IFT140 cause non-syndromic retinal degeneration Hum Genet. 2015 Oct;134(10):1069-78. doi: 10.1007/s00439-015-1586-x. Epub2015 Jul 28.

783. Bankhead, E.J., Colasanto, M.P., Dyorich, K.M., Jamrich, M., Murtaugh, L.C., Fuhrmann, S. (2015). Multiple Requirements of the Focal Dermal Hypoplasia Gene Porcupine during Ocular Morphogenesis. Am J Pathol. 185:197-213.

784. Zhong, H, Chen Y, Li, Y, Chen, R, Mardon, G. CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes. Scientific Reports. 2015 Feb 10;5:8366 doi:10.1038/srep08366. PubMed PMID: 25666713

785. H Zhong, A Eblimit, Y Moayedi, SL Boye, VA Chiodo, Y Chen, Y Li, RM Nichols, WW Hauswirth, R Chen, G. Mardon. AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa. Gene Therapy. 2015 Aug;22(8):619-27. doi:10.1038/gt.2015.42.Epub 2015 May 12.

786. Gersztenkorn D, Coletta C, Zhu S, Ha Y, Liu H, Ding Y, Zhou J, Szabo C, Zhang, W, Motamedi M. The cystathionine gamma-lyase/hydrogen sulfide pathway is involved in pathological retinal neovascularization in ischemic retinopathy. Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4689. (ARVO meeting abstract)

787. Zhang W, Zhu S, Ali S, Martirossian AN, Hu X, Al-Enazy S, Albekairi N, Motamedi M, Rytting E. Nanoparticle-medicated delivery of hydrophobic compounds to retinal microvascular endothelial cells. Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4160. (ARVO meeting abstract)

788. Hein TW, Rosa RH Jr, Ren Y, Xu W, and Kuo L. VEGF receptor-2-linked PI3K/Calpain/SIRT1 activation mediates retinal arteriolar dilations to VEGF and shear stress. Invest Ophthalmol Vis Sci 56:5381-5389, 2015.

789. Singh R, Kuai D, Guziewicz KE, Meyer J, Wilson M, Lu J, Smith M, Clark E, Verhoeven A, Aguirre GD, Gamm, DM. Pharmacological modulation of photoreceptor outer segment degradation in a human iPS cell model of inherited macular degeneration. Mol Ther. 2015 Aug 24. (Epub ahead of print). PubMed PMID:26300224.

790. Basavarajappa HD, Lee B, Lee H, Sulaiman RS, An H, Magaña C, Shadmand M, Vayl A, Rajashekhar G, Kim E-Y, Suh Y-G, Lee K, Seo S-Y, Corson TW. 2015. Synthesis and biological evaluation of novel homoisoflavonoids for retinal neovascularization. Journal of Medicinal Chemistry, 58, 5015-5027.

791. Sulaiman RS, Quigley J, Qi X, O’Hare MN, Grant M, Boulton ME, Corson TW. 2015. A simple optical coherence tomography quantification method for choroidal neovascularization. Journal of Ocular Pharmacology and Therapeutics, 31, 447-54.

792. Cecinio C. Ronquillo CC, Li Jiang L, Hanke-Gogokhia C, Gerstner CD, Revelo MP, Jeanne M. Frederick JM and Baehr W (2015). The Nphp5-/- mouse: a model for Leber Congenital Amaurosis. Submitted to Hum. Mol. Genetics.

793. Hanke-Gogokhia C, Wu Z, Frederick JM, Gerstner CD, Zhang H, Baehr W (2015). The function of ARL3 in photoreceptors. Submitted to eLife.

2014 Publications by RRF Grant Recipients

762. Tse, D.Y., Chung I. and Wu S.M. (2014a) “Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.”  Vision Res., 103: 49-62.

763. Tse, D.Y., Chung I. and Wu S.M. (2014b) “Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses.” Vision Res., 103: 63-74.

764. Ressler, S.J., Dang, T.D., Wu, S.M., Tse, D.Y., Gilbert, B.E., Vyakarnam, A., Yang, F., Schauer, I.G., Barron, D.A. and Rowley, D.R. (2014) “WFDC1 is a Key Modulator of Inflammatory and Wound Repair Responses.” American J. of Pathology, 184,11: 2951-2964.

765. Wang F, Wang Y, Zhang B, Zhao L, Lyubasyuk V, Wang K, Xu M, Li Y, Wu F, Wen C, Bernstein PS, Lin D, Zhu S, Wang H, Zhang K, Chen R. “A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa.” Invest Ophthalmol Vis Sci. 2014 Oct 14. PMID: 25316723.

—(reported “in press” 2013)— Keeley PW, Luna G, Skyles KA, Madsen N, Raven MA, Poche RA, Behringer RR, Swindell EC, Jamrich M, Fisher SK and Reese BE (2014) “Development and Plasticity of Outer Retinal Circuitry Following Genetic Removal of Horizontal Cells.” J. Neurosci. 33, 17847-62.

766. Sauter MM, Gauger JJ, Brandt CR. “Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps.” Antiviral Res. 109:83-96, 2014.

767. Luke B. Potts, Patrick D. Bradley, Wenjuan Xu, Lih Kuo, and Travis W. Hein. “Role of Endothelium in Vasomotor Responses to Endothelin System and Protein Kinase C Activation in Porcine Retinal Arterioles.” Invest. Ophthalmol. Vis. Sci. 54:7587-7594, 2013.

768. Sulaiman RS, Basavarajappa HD, Corson TW. 2014. “Natural product inhibitors of ocular angiogenesis.” Experimental Eye Research, DOI:10.1016/j.exer.2014.10.002.

769. Lee B, Basavarajappa HD, Sulaiman RS, Fei X, Seo S-Y, Corson TW. 2014. “First synthesis of the antiangiogenic homoisoflavanone, cremastranone.” Organic and Biomolecular Chemistry, 12, 7673-7677.

770. Basavarajappa HD, Lee B, Fei X, Lim D, Callaghan B, Mund JA, Case J, Rajashekhar G, Seo SY, Corson, TW. 2014. “Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.” PLoS ONE, 9, e95694.

771. Zhang M, Covar J, Zhang YN, Marshall B, Mo J, Atherton SS. “Virus spread and immune response following anterior chamber inoculation of HSV-1 lacking the Beclin-Binding Domain (BBD).” J. Neuroimmunol. 2013;260:82-91.

772. Mo J, Zhang M, Smith S, Marshall B, Atherton SS. “Interplay of autophagy and apoptosis during MCMV infection of RPE cells.” Molecular Vision. 2014;20:1161-1173.

773. Marshall B, Mo J, Covar J, Atherton SS, Zhang M. “Decrease of Murine Cytomegalovirus Induced Retinitis by Intravenous Delivery of Immediate Early Protein-3 Specific siRNA.” Invest. Ophthalmol. Vis. Sci. 2014;55:4151-7.

774. Mo J, Marshall B, Covar J, Smith SB, Atherton SS, Zhang M. “Role of Bax in death of uninfected retinal cells during murine cytomegalovirus (MCMV) retinitis.” Invest. Ophthalmol. Vis. Sci. 2014 Oct 8. pii: IOVS-14-15404. doi: 10.1167/iovs.14-15404.

2013 Publications by RRF Grant Recipients

747. Frankfort B, Khan AK, Tse DY, Chung I, Pang JJ, Yang Z, Gross R, and Wu SM (2013) “Elevated intraocular pressure causes inner retinal dysfunction prior to cell loss in a mouse model of experimental glaucoma.” Invest. Ophthal. Vis. Scien., 54, 1: 762-770.

748. Pang JJ, Paul DL, and Wu SM (2013) “Survey on amacrine cell coupling to retrograde-identified ganglion cells in the mouse retina.” Invest. Ophthalmol. Vis. Sci. 1; 54: 5151-62.

749. Gao F, Pang JJ and Wu SM (2013) “Sign-preserving and sign-inverting rod-cone interactions in the salamander retina.” J. Physiology, 00, 1-16.

750. Qing Fu, Feng Wang, Hui Wang, Fei Xu, Jacques Zaneveld, Huanan Ren, Vafa Keser, Irma Lopez, Hang-Fang Tuan, Jason Salvo, Xia Wang, Li Zhao, Keqing Wang, Yumei Li, Robert Koenekoop, Rui Chen, Ruifang Sui “Next Generation Sequencing Based Molecular Diagnosis of a Chinese Patient Cohort with Autosomal Recessive Retinitis Pigmentosa.” IOVS, 2013 Jun 14;54(6):4158-66.

751. Wang X, Wang H, Sun V, Tuan HF, Keser V, Wang K, Ren H, Lopez I, Zaneveld JE, Siggiqui S, Bowles S, Khan A, Salvo J, Jacobson SG, Iannaccone A, Wang F, Birch D, Heckenlively JR, Fishman GA, Traboulsi EI, Li Y, Wheaton D, Koenekoop RK, Chen R “Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing.” J Med Genet. 2013 July 11 PMID: 23847139.

752. Wang F, Wang H, Tuan HF, Nguyen DH, Sun V, Keser V, Bowne SJ, Sullivan LS, Luo H, Zhao L, Wang X, Zaneveld JE, Salvo JS, Siddiqui S, Mao L, Wheaton DK, Birch DG, Branham KE, Heckenlively JR, Wen C, Flagg K, Ferreyra H, Pei J, Khan A, Ren H, Wang K, Lopez I, Qamar R, Zenteno JC, Ayala-Ramirez R, Buentello-Volante B, Fu Q, Simpson DA, Li Y, Sui R, Silvestri G, Daiger SP, Koenekoop RK, Zhang K, Chen R “Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements.” Hum Genet. 2013 Oct 24. [Epub ahead of print]

753. Bond WS, Akinfenwa PY, Perlaky L, Hurwitz, MY, Hurwitz, RL, Chévez-Barrios, P. “Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors are of Malignant Origin.” PLoS ONE 8(6): e63519. Doi:10.1371/journal.pone.0063519, 2013. PMID: 23658322.

754. Lu F, Kar D, Gruenig N, Cousins N, Rodgers H, Swindell E, Jamrich M, Schuurmans C, Mathers P, and Kurrasch D (2013) “Rax is a selector gene for the establishment of hypothalamic feeding circuits.” J. Neurosci. 33, 259-272.

755. Nasonkin IO, Merbs SL, Lazo K, Oliver V, Brooks M, Patel K, Enke RA, Nellissery J, Jamrich M, Le YZ, Bharti K, Rachel RA, Fariss RN, Zack DJ, Rodriguez-Boulan EJ, Swaroop A (2013) “Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a critical role of retinal pigment epithelium integrity in photoreceptor development.” Development 140, 1330.

756. Keeley PW, Luna G, Skyles KA, Madsen N, Raven MA, Poche RA, Behringer RR, Swindell EC, Jamrich M, Fisher SK and Reese BE (2014) “Development and Plasticity of Outer Retinal Circuitry Following Genetic Removal of Horizontal Cells.” J. Neurosci. (in press)

757. Atkins M, Jiang, Sansores-Garcia L, Jusiak B, Halder G, Mardon G (2013) “Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.” PLoS Genetics, Aug;9(8):e1003731. PMID: 24009524. PMCID: PMC3757064.

758. Jin M, Jusiak B, Bai Z, Mardon G (2013) “Eyes absent Tyrosine Phosphatase Activity is Not Required for Drosophila Development or Survival.” PLoS One, 8(3):e58818. PMCID: PMC3595212.

759. Haase-Gilbert E, Kwak SJ, Chen R, Mardon G (2013) “Drosophila signal peptidase complex member spase12 is required for normal development and cell differentiation.” PLoS One, 8(4):e60908. PMID: 23573290. PMC3616019.

760. Potts LB, Ren Y, LuG, Kuo E, Ngo E, Kuo L, Hein TW “Constriction of retinal arterioles to endothelin-1: requisite role of Rho kinase independent of protein kinase C and L-type calcium channels.” Invest Ophthalmol. Vis. Sci. 53:2904-2912, 2012.

761. Hein TW, Potts LB, Xu W, Yuan Z, Kuo L “Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes.” Invest. Ophthalmol. Vis. Sci. 53: 7943-7949, 2012.

2012 Publications by RRF Grant Recipients

732. Price, B., Sandoval, I.M., Chan, F., Simons, D.L., Wu, S.M., Wensel, T.G. and Wilson, J.H. (2011) “Mislocalization and degradation of human P23H-rhodopsin-GFP in a knock-in mouse model of retinitis pigmentosa,” Invest. Ophthal. Vis. Scien., 52, 13, 9728-9736.

733. Pang, J.J., Gao, F. and Wu, S.M. (2012) “Physiological characterization and functional heterogeneity of narrow-field mammalian amacrine cells,” J. Physiology, 590, 1, 223-234.

734. Pang, J.J., Gao, F., Paul, D. L. and Wu, S.M. (2012) “Rod, M-cone and M/S-cone inputs to hyperpolarizing bipolar cells in the mouse retina,” J. Physiology, 590, 4, 845-854.

735. Pang, J.J., Gao, F. and Wu, S.M. (2012) “Ionotropic glutamate receptors mediate OFF responses in light-adapted depolarizing bipolar cells,” Vision Research, 68, 48-58.

736. Cho, SH, Kim JY, Simons DL, Song JY, Le JH, Swindell EC, Jamrich M, Wu SM, Kim S (2012) “Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis,” Hum Mol Genet. 21(12):2663-76.

737. B.J. Frankfort, A.K. Khan, D.Y. Tse, I. Chung, J.J. Pang, Z. Yang, R.L. Gross, and S.M. Wu, “Elevated intraocular pressure causes inner retinal dysfunction prior to cell loss in a mouse model of experimental glaucoma,” in review.

738. Hui Wang, Xianfeng Chen, Lynn Dudinsky, Claire Patenia, Yiyun Chen, Yumei Li, Yue Wei, Emad B. abboud, Ali A. Al-Rajhi, Richard Alan Lewis, James R. Lupski, Graeme Mardon, Richard A. Givvs, Brian D. Perkins, Rui Chen (2011) “Exome capture sequencing identifies a novel mutation in BBS4,” Molecular Vision 2011, 17:3529-40. PMID: 22219648.

739. Zhi D, Chen R (2012) “Statistical Guidance for Experimental Design and Data Analysis of Mutation Detection in Rare Monogenic Mendelian Diseases by Exome Sequencing.” PloS ONE 7(2):e31358. doi:10.1371/journal.pone.0031358

740. Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Naqeeb M, FORGE Canada Consortium, Leeds Study Group, Keser V, Mardon G, Xu H, Inglehearn CF, Fu Q, Toomes C, Chen R “Mutant NMNAT1 causes human blindness due to Leber congenital amaurosis: the elusive LCA9 gene.” Nature Genetics 2012, 44(9):1035-9.

741. Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, XU HP, Jamrich M, Itohara S, Feller MB and Crair MC (2012) “Role of adenylate cyclase 1 in retinofugal map development.” J. Comp. Neurol. 520, 1562-1583.

742. Wadhwa L, Bond WS, Perlaky L, Overbeek P, Hurwitz MY, Hurwitz RL, Chévez-Barrios P. “Embryonic Retinal Tumors in SV40-T-Ag Transgenic Mice Contain CD133+ Tumor-initiating Cells.” Invest. Ophthalmol. Vis Sci. 53, 3454-3462, 2012, epub PMID:22562503.

743. Ildefonso CJ, Bond WS, Altawashi AR, Hurwitz MY, Hurwitz RL. “The Liberation of CD44 Intracellular Domain Modulates Adenoviral Vector Transgene Expression.” J. Biol. Chem. 287, 32697-32707, 2012, PMID:22865879.

744. Hurwitz RL. “A New Vision of Mesenchymal Stem Cells.” Mol. Therapy 20:2017-2018, 2012. PMID:23131854.

745. Travis W. Hein, Yi Ren, Luke B. Potts, Zhaoxu Yuan, Enoch Kuo, Robert H. Rosa, Jr. and Lih Kuo “Acute Retinal Ischemia Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production.” IOVS January 2012, Vol. 53, No. 1, 30-36.

746. Luke B. Potts, Yi Ren, Guangrong Lu, Enoch Kuo, Ellen Hgo, Lih Kuo and Travis W. Hein “Constriction of Retinal Arterioles to Endothelin-1: Requisite Role of Rho Kinase Independent of Protein Kinase C and L-Type Calcium Channels.”  IOVS May 2012, Vol. 53, No. 6, 2904-2912.

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Mission of RRF

The mission of the Retina Research Foundation is to reduce retinal blindness worldwide by funding programs in research and education. As a public charity, RRF raises funds from the private sector and the investment of its endowment funds.

RRF’s 48th Anniversary

October 1, 2017