Each year, RRF funded scientists significantly contribute to the collective body of knowledge about retinal disease through their publications in peer reviewed journals – 981 articles since 1978.

2024 Publications by RRF Grant Recipients

981.  Angela R. MacIsaac, J. Wellington, Kyle Filicetti, Erika D. Eggers. Impaired dopamine signaling in early diabetic retina: Insights from D1R and D4R agonist effects on whole retina responses. Experimental Eye Research, Volume 247, October 2024, 110049. https://doi.org/10.1016/j.exer.2024.110049.

980.  Wu, Samuel, Pang, Jie. Effects of elevated intraocular pressure on alpha ganglion cells in experimental glaucoma mice, 2024/08/31. Vision research, 108475, 224. 10.1016/j.visres.2024.108475

979.  Long, Ye, Kozhemyakin, Maxim, Wu, Samuel, Pang, Jie. TRPV4 affects visual signals in photoreceptors and rod bipolar cells, 2024/06/05. Frontiers in cellular neuroscience. 1404929, 18, 10.3389/fncel.2024.1404929.

978.  Pang, Jie, Jiang, Xiaolong, Wu, Samuel. Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network. The Journal of Neuroscience, 2024/02/29. e1433232024, VL – 44. 10.1523/JNEUROSCI.1433-23.2024.

977.  Poppy Datta, Kun-Do Rhee, Rylee J. Staudt, Jacob M. Thompson, Ying Hsu, Salma Hassan, Arlene V. Drack, Seongjin Seo. Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system. Human Molecular Genetics, 2024, 1–17. https://doi.org/10.1093/hmg/ddae144.

976. Jessica D. Bills, Ashley W. Seifert, Ann C. Morris. Retinal neuroanatomy of two emerging model organisms, the spiny mouse (Acomys dimidiatus) and the Mongolian gerbil (Meriones unguiculatus) Experimental Eye Research 247 (2024) 110055. https://doi.org/10.1016/j.exer.2024.110055

Francesco Giorgianni, and Sarka Beranova-Giorgianni. Ubiquitin-proteasome activation in retinal pigment epithelial 2 (RPE) cells in response to oxidized low density lipoprotein (Ox- 3 LDL). 4,* Biomedicines 2024, 12, x. https://doi.org/10.3390/xxxxx. www.mdpi.com/journal/biomedicine. Pre-press

975. Fu, Y., Zhang, Z., Webster, K. & Paulus, Y. (2024). Treatment Strategies for Anti-VEGF Resistance in Neovascular Age-Related Macular Degeneration by Targeting Arteriolar Choroidal Neovascularization. Biomolecules. 14(3):252. https://sciencefeatured.com/2024/08/01/overcoming-drug-resistance-in-macular-degeneration/

Zhang, Z., Ahir, M. & Fu, Y. AAV mediated expression of AIBP, apoA-I, and aflibercept overcomes anti-VEGF resistance in neovascular AMD. Exploration of Medicine. Under revision.

 PATENT FILING.  Corson TW, Kelley MR, Song Y. Methods of inhibiting retinal degeneration. U.S. Provisional Patent Application 63/642,293, filed 3 May 2024

974.  Fei X, Jung S, Kwon S, Kim J, Corson TW, Seo S-Y. 2024. The challenges and opportunities of developing small molecule therapies for age-related macular degeneration. Archives of Pharmacal Research, 47, 538–557.

973.  Qian X, Srinivasan T, He J, Lu J, Jin Y, Gu H, Chen R. Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model. Dis Model Mech. 2023 Jul 1;16(7):dmm050168. doi: 10.1242/dmm.050168. Epub 2023 Jul 19. PMID: 37466006; PMCID: PMC10387349.

972. Lu J, Zheng KQ, Bertrand RE, Quinlan J, Ferdous S, Srinivasan T, Oh S, Wang K, Chen R. Gene augmentation therapy to rescue degenerative photoreceptors in a Cwc27 mutant mouse model. Exp Eye Res. 2023 Jul 20;234:109596. doi: 10.1016/j.exer.2023.109596. Epub ahead of print. PMID: 37479075.

971. Theodore Edward Margo, Frank Sungping Chen, Yu-Jiun Chen and Ching-Kang Chen,Grk1 Missense Mutations in Type II Oguchi Disease: A Literature Review. Ann Biomed Res Vol 5(2): 1-7. DOI: 10.61545/ABR-5-128.

970.  Ma, J., Chu, T.K., Prieto, M.P., Park, Y., Li, Y., Chen, R., Mardon, G.,Frankfort, B.J, Tran, N.M, Sample multiplexing for retinal single-cell RNA-sequencing, ISCIENCE (2024), doi: https://doi.org/10.1016/j.isci.2024.111250.

969.  Li J, Choi J, Cheng X, Ma J, Pema S, Sanes JR, Mardon G, Frankfort BJ, Tran NM, Li Y, Chen R. Comprehensive single-cell atlas of the mouse retina (2024). iScience. 2024 May 8;27(6):109916. doi: 10.1016/j.isci.2024.109916. eCollection Jun 21. PMID: 38812536. PMCID: PMC11134544

968.   Raja KKB, Yeung K, Li Y, Chen R, Mardon G. A single cell RNA sequence atlas of the early Drosophila larval eye (2024).. BMC Genomics. Jun 19;25(1):616. doi: 10.1186/s12864-024-10423-x. PMID: 38890587. PMCID: PMC11186242

967.  Wang, H., Raja, K., Yeung, K., Morrison, C., Terrizzano, A., Khodadadi-Jamayran, A., Chen, P., Jordan, A., Fritsch, C., Sprecher, S., Mardon, G., and Treisman, J. Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc (2024). Nat Commun. 2024 Aug 17;15(1):7091. doi: 10.1038/s41467-024-51429-z. PMID: 39154080. PMCID: PMC11330500.

966.  P. Shang, H. Ambrosino, J. Hoang, Z. Geng, X. Zhu, S. Shen, M. Eminhizer,
E. Hong, M. Zhang, J. Qu, J. Du, S.R. Montezuma, J.R Dutton, D.A. Ferrington, The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium, Free Radical Biology and Medicine, https://doi.org/10.1016/j.freeradbiomed.2024.10.307.

965. Brock DC, Wang M, Hussain HMJ, Rauch DE, Marra M, Pennesi ME, Yang P, Everett L, Ajlan RS, Colbert J, Porto FBO, Matynia A, Gorin MB, Koenekoop RK, Lopez I, Sui R, Zou G, Li Y, Chen R. Comparative analysis of in-silico tools in identifying pathogenic variants in dominant inherited retinal diseases. Hum Mol Genet. 2024 Mar 7:ddae028. doi: 10.1093/hmg/ddae028. Epub ahead of print. PMID: 38453143.

964. Han JH, Rodenburg K, Hayman T, Calzetti G, Kaminska K, Quinodoz M, Marra M, Wallerich S, Allon G, Nagy ZZ, Knézy K, Li Y, Chen R, Barboni MTS, Yang P, Pennesi ME, van den Born LI, Varsányi B, Szabó V, Sharon D, Banin E, Ben-Yosef T, Roosing S, Koenekoop RK, Rivolta C. Loss-of-function variants in UBAP1L cause autosomal recessive retinal degeneration. Genet Med. 2024 Feb 26:101106. Epub ahead of print. PMID: 38420906.

963. Anara Serikbaeva, Yanliang Li, Simon Ma, Darvin Yi, Andrius Kazlauskas. Resilience to diabetic retinopathy. Progress in Retinal and Eye Research 101 (2024) 101271. https://doi.org/10.1016/j.preteyeres.2024.101271.

962.  Fan Xia, Shuizhen Shi, Erick Palacios, Wei Liu, Seth E. Buscho, Joseph Li, Shixia Huang, Gianmarco Vizzeri, Xiaocheng Charlie Dong, Massoud Motamedi, Wenbo Zhang and Hua Liu. Sirt6 protects retinal ganglion cells and optic nerve from degeneration during aging and glaucoma. Molecular Therapy (2024). https://doi.org/10.1016/j.ymthe.2024.04.030.

961.  Xiao J. Tong, Gokhan Akdemir, Meetu Wadhwa, Alan S. Verkman and Alex J. Smith. Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice. Fluids and Barriers of the CNS (2024) 21:1 https://doi.org/10.1186/s12987-023-00506-4.

2023 Publications

960.  Monica M. Sauter, Hongyu Noel, Curtis R. Brandt. The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells. Experimental Eye Research, Volume 236, November 2023, 109647. https://doi.org/10.1016/j.exer.2023.109647

959.  Buscho, S.E.; Xia, F.; Shi, S.; Lin, J.L.; Szczesny, B.; Zhang, W.; Motamedi, M.; Liu, H. Non-Invasive Evaluation of Retinal Vascular Alterations in a Mouse Model of Optic Neuritis Using Laser Speckle Flowgraphy and Optical Coherence Tomography Angiography. Cells 2023, 12, 2685. https://doi.org/10.3390/cells12232685.

958. Hussain H Muhammad J, Wang M, Huang A, Schmidt R, Qian X, Yang P, Marra M, Li Y, Pennesi ME, Chen R. Novel Pathogenic Mutations Identified from Whole-Genome Sequencing in Unsolved Cases of Patients Affected with Inherited Retinal Diseases. Genes (Basel). 2023 ;14(2). 447.

957. Wen S, Wang M, Qian X, Li Y, Wang K, Choi J, Pennesi ME, Yang P, Marra M, Koenekoop RK, Lopez I, Matynia A, Gorin M, Sui R, Yao F, Goetz K, Porto FBelga Otto, Chen R. Systematic assessment of the contribution of structural variants to inherited retinal diseases. Hum Mol Genet. 2023 Jun 5;32(12):2005-2015.

956. Qian X, Srinivasan T, He J, Lu J, Jin Y, Gu H, Chen R. Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model. Dis Model Mech. 2023 Jul 1;16(7):dmm050168.

955. Lu J, Zheng KQ, Bertrand RE, Quinlan J, Ferdous S, Srinivasan T, Oh S, Wang K, Chen R. Gene augmentation therapy to rescue degenerative photoreceptors in a Cwc27 mutant mouse model. Exp Eye Res. 2023 Jul 20;234:109596. Epub ahead of print.

954. Nassief S, Amer M, Shawky E, Sishtla K, Mas-Claret E, Muniyandi A, Corson TW, Mulholland DL, Elmasry S. 2023. Antiangiogenic polyphenolics from Erythrina lysistemon Hutch. Journal of Natural Products, 86, 759–766

953. Muniyandi A, Hartman GD, Song Y, Mijit M, Kelley MR*, Corson TW.* 2023. Beyond VEGF: targeting inflammation and other pathways for treatment of retinal disease. Journal of Pharmacology & Experimental Therapeutics, 386, 15–25. *equal contributors.

952. Park B, Sardar Pasha SPB, Sishtla KL, Hartman GD, Qi X, Boulton ME, Corson TW. 2022. Decreased expression of soluble epoxide hydrolase suppresses murine choroidal neovascularization. International Journal of Molecular Sciences, 23, 15595

951. Meghashri Saravanan, Rong Xu, Olivia Roby, Yekai Wang, Siyan Zhu, Amy Lu, Jianhai Du. Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States. Investigative Ophthalmology Vision Science. 2023 Mar 1;64(3):18. doi: 10.1167/iovs.64.3.18.

950.     Siyan Zhu, Rong Xu, Abbi L. Engel, James B. Hurley, Jennifer R. Chao, Jianhai Du. Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina. Journal of Biological Chemistry. 2023 doi:10.1016/j.jbc.2023.105275

949.     Eggers ED. Visual Dysfunction in Diabetes. Annual Reviews in Vision Science, (2023) 9: 91-109.

948.     Attarde A, Riad TS, Zhang Z, Ahir M, and Fu Y (2023). Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography. JoVE (Journal of Visualized Experiments), e65682. 10.3791/65682.

947.     Pan Y, Fu Y, Baird PN, Guymer RH, Das T, and Iwata T. (2022). Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration. Prog Retin Eye Res, 101159. 10.1016/j.preteyeres.2022.101159

914.     Xu H, Jin N, Chuang J-Z, Zhang Z, Zhong X, Zhang Z, Sung C-H, Ribelayga CP, Fu Y (2022). Visual pigment deficient cones survive and mediate visual signaling despite the lack of outer segments. Proc Natl Acad Sci U S A. 119(9). doi:10.1073/pnas.2115138119. (initially reported under revision in 2021)

946.     Nguyen, VP, Henry, J, Zhe, J, Kieu, Q, Qian, W, Fu, Y, Wang, X, and Paulus, YM. (2022). Age differential response to bevacizumab therapy in choroidal neovascularization in rabbits. Exp. Eye Res. 223, 109215. https://doi.org/10.1016/j.exer.2022.109215.

945.     Li Y, Baccouche B, Del-Risco N, Park J, Song A, McAnany J, Kazlauskas A. The slow progression of diabetic retinopathy is associated with transient protection of retinal vessels from death. Int J Mol Sci. 2023 June 29;24(10):10869

944.     A Single Cell Genomics Atlas of the Drosophila Larval Eye Reveals Distinct Developmental Timelines and Novel Markers for All Photoreceptor Subtypes (2023). Raja, K., Yeung, K., Shim, Y-K., Li, Y., Chen, R., and Mardon, G. Nature Communications, volume 14, Article number: 7205 (2023). Published 11/08/2023.

943.  Seilheimer R.L., McClard, C.K., Sabharwal J. and Wu S.M. (2023) Modulation of narrow-field amacrine cells on light-evoked spike responses and receptive fields of retinal ganglion cells. Vision Research, 205, 108186. PMID: 36764009

942.   Pang J.J., Gao, F. and Wu, S.M. (2023) Light responses and amacrine cell modulation of morphologically identified retinal ganglion cells in the mouse retina. Vision Research, 205, 108187, PMID: 38758452.

941.  Ryan Ash, Ganna Palagina, Jose Fernandez-Leon, Jiyoung Park, Rob Seilheimer, Sangkyun Lee, Jasdeep Sabharwal, Fredy Reyes, Jing Wang, Dylan Lu, Muhammad Sarfraz, Emmanouil Froudarakis, Andreas Tolias, Samuel M. Wu, and Stelios Smirnakis (2023) Increased reliability of visually-evoked activity in area V1 of the MECP2-duplication mouse model of autism. J. Neuroscience, 42 (33): 6469- 6482. PMID: 35831173.

940.  Zhang X, Xu J, Marshall B, Dong Z, Liu Y, Espinosa-Heidmann DG, Zhang M*. Transcriptome analysis of retinal and choroidal pathologies in aged BALB/c mice following systemic neonatal murine cytomegalovirus infection. Int. J. Mol. Sci. 2023; 24(5):4322. https://doi.org/10.3390/ijms2405432 PMCID: PMC10001583; PMID: 36901754

939.  Shuizhen Shi, Chun Ding, Shuang Zhu, Fan Xia, Seth E. Buscho, Shengguo Li, Massoud Motamedi, Hua Lui, and Wenbo Zhang. PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy. IVOS, August 2023, Vol. 64, No.11, Article 17.

2022 Publications 

938. Seth Buschoa, Erick Palaciosa, Fan Xiaa, Shuizhen Shia, Shengguo Lia, Jonathan Luisia, Rakez Kayed, Massoud Motamedia, Wenbo Zhang, Hua Liua. Longitudinal characterization of retinal vasculature alterations with optical coherence tomography angiography in a mouse model of tauopathy. Experimental Eye Research, Volume 224, November 2022, 109240.

937.  Sivan Zhu, Jiancheng Huang, Rong Xu, Chen Zhao, Jenna Sigado, Jianhai Du, Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.JBioChem:298.9,102387, September 2022. DOI: https://doi.org/10.1016/j.jbc.2022.102387

936. Abbie L. Engel, YeKai Wang, Thomas H. Khuu, Emily Worrall, Megan A. Manson, Rayne R. Lim, Kaitlen Knight, Ava Yanagida, Jian Hua Qi, Aravid Ramakrishnan, Richard G. Weleber, Michael L. Klein, David J. Wilson, Bela Anand-Apte, James B. Hurley, Jianhai Du,  Jennifer R. Chao. Extracellular matrix dysfunction in Sorsby patient-derived retinal pigment epithelium. Experimental Eye Research. 215 February 2022, 108899. https://doi.org/10.1016/j.exer.2021.108899

935. Rosa, Robert & Xie, Wankun & Zhao, Min & Tsai, Shu-Huai & Hein, Travis & Kuo, Lih. (2022). Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa. American Journal of Ophthalmology. 239. 10.1016/j.ajo.2022.03.014.

934. Qian X, Liu H, Fu S, Lu J, Hung Y-T, Turner C, Gu H, Chen R. AAV8-Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model. Invest Ophthalmol Vis Sci. 2022 ;63(3):11

933.Marques J Pedro, Porto F Belga Otto, Carvalho A Luísa, Neves E, Chen R, Sampaio Saparecida, Murta J, Saraiva J, Silva R. EYS-Associated Sector Retinitis Pigmentosa. Graefes Arch Clin Exp Ophthalmol. 2022 ;260(4):1405-1413 PMID: 34568954

932.Tehreem R, Chen I, Shah MR, Li Y, Khan MA, Afshan K, Chen R, Firasat S. Exome Sequencing Identified Molecular Determinants of Retinal Dystrophies in Nine Consanguineous Pakistani Families. Genes (Basel). 2022 Sep 10;13(9):1630. doi: 10.3390/genes13091630. PMID: 36140798; PMCID: PMC9498396.

931. Zhang, Z., Shen, M.M., and Fu, Y. (2022). Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization. Investigative Ophthalmology & Visual Science 63 (12), 2. doi: https://doi.org/10.1167/iovs.63.12.2.

930. Submitted: Park B, Sardar Pasha SPB, Sishtla KL, Hartman GD, Qi X, Boulton ME, Corson TW. AAV8 mediated expression of shRNA targeting soluble epoxide hydrolase suppresses murine choroidal neovascularization.

929. Sishtla K, Lambert-Cheatham N, Lee B, Han DH, Park J, Pran Babu SPS, Lee S, Kwon S, Muniyandi A, Park B, Odell N, Waller S, Park IL, Lee SJ, Seo S-Y, Corson TW. 2022. Novel small molecule inhibitors of ferrochelatase are antiangiogenic agents. Cell Chemical Biology, doi: 10.1016/j.chembiol.2022.01.001. PubMed.

928. Francesco Giorgianni, Sarka Beranova-Giorgianni, Oxidized low-density lipoprotein causes ribosome reduction and inhibition of protein synthesis in retinal pigment epithelial cells, Biochemistry and Biophysics Reports, Volume 32, 2022, 101345, ISSN 2405-5808, https://doi.org/10.1016/j.bbrep.2022.101345.

927. Prepress: Seilheimer R.L., Sabharwal J. and Wu S.M. (2022) Modulatory actions of narrow-field amacrine cells on light-evoked spike responses and receptive field properties of retinal ganglion cells. Submitted to Vision Research.

926. Prepress: Pang J.J., Gao, F. and Wu, S.M. (2022) Light responses and amacrine cell modulation of morphologically-identified retinal ganglion cells in the mouse retina. Submitted to Vision Research.

 925. Lu, J., Xiong, K., Qian, X. Choi, J., Shim, YK., Burnett, J., Mardon, G., Chen, R., Spata7 is required for maintenance of the retinal connecting cilium. Sci Rep 12, 5575 (2022). https://doi.org/10.1038/s41598-022-09530-0

924. Reed M, Takemaru K-I, Ying G, Frederick JM, Baehr W (2022) Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interruptsciliary intraflagellar transport(IFT). PLoS Genet 18(9): e1010154.https://doi.org/10.1371/journal. pgen.1010154.

2021 Publications

923. Renae Elaine Bertrand, Jun Wang, Kaitlyn H Xiong, Chinthana Thangavel, Xinye Qian, Rola Ba-Abbad, Qingnan Liang, Renata T Simões, Shirley A M Sampaio, Keren J Carss, F Lucy Raymond, Anthony G Robson, Andrew R Webster, Gavin Arno, Fernanda Belga Ottoni Porto, Rui Chen. Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy. Genet Med. 2021;23(3):488-497.

922. De-Quan Li, Sangbae Kim, Jin-Miao Li, Qianmiao Gao, Jongsu Choi, Fang Bian, Jiaoyue Hu, Yun Zhang, Jin Li, Rong Lu, Yumei Li, Stephen C Pflugfelder, Hongyu Miao, Rui Chen Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea. Ocul Surf. 2021;20:20-32.

921. Wang, J, Liu, H, Bertrand, R Elaine, Sarrion-Perdigones, A, Gonzalez, Y, Venken, KJT, Chen, R. A novel statistical method for interpreting the pathogenicity of rare variants. Genet Med. 2021;23(1):59-68.

920. Zou, G, Zhang, T, Cheng, X, Igelman, AD, Wang, J, Qian, X, Fu, S, Wang, K, Koenekoop, RK, Fishman, GA, Yang, P, Li, Y, Pennesi, ME, Chen, R Noncoding mutation contributes to inherited retinal degenerations. Mol Vis. 2021;27:95-106.

 919. Qian X, Wang J, Wang M, Igelman AD, Jones KD, Li Y, Wang K, Goetz KE, Birch DG, Yang P, Pennesi ME, Chen R. Identification of Deep-Intronic Splice Mutations in a Large Cohort of Patients with Inherited Retinal Diseases. Front Genet. 2021;12:647400.

 918. Sardar Pasha SPB, Shetty T, Lambert-Cheatham NA, Sishtla K, Mathew D, Muniyandi A, Patwari N, Bhatwadekar AD, Corson TW. 2021. Retinal phenotyping of ferrochelatase mutant mice reveals protoporphyrin accumulation and reduced neovascular response. Investigative Ophthalmology and Visual Science, 62, 36.

917. Chobisa D, Sishtla KL, Corson TW, Yeo Y. Sustained delivery of griseofulvin by polymeric microparticles for neovascular eye disease treatment. Poster presentation at the virtual ARVO, May 2021. Investigative Ophthalmology & Visual Science, 62: E-abstract 199.

916. Jacobs B, Palmer N, Shetty T, Dimaras H, Hajrasouliha A, Jusufbegovic D, Corson TW. Patient preferences in retinal drug delivery. Scientific Reports, 11, 18996.

915. Zhu L, Parker M, Enemchukwu N, Shen M, Zhang G, Yan Q, Handa J, Fang L, and Fu Y (2020). Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice. Commun Biol. 3(1):386. doi: 10.1038/s42003020-1113-z.

914. Xu H, Enemchukwu N, Zhong X, Zhang O, and Fu Y (2020). Deletion of M-opsin prevents “M cone” degeneration in a mouse model of Leber congenital amaurosis. Am J Pathol. 190(5):1059-1067. PMCID: PMC7237827.

913. Xu H, Jin N, Chuang JZ, Zhang Z, Zhong X, Zhang ZJ, Sung CH, Ribelayga C, and Fu Y. Visual pigment deficient cones survive and mediate visual signaling despite the lack of outer segment (2021). Under revision. This paper was submitted to a high impact journal Proceedings of the National Academy of Sciences of the United States of America and got very positive reviews.

912. Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Satoru Yamagami, Akifumi Kushiyama, Lih Kuo & Taiji Nagaoka. Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice. Nature Scientific Reports (2021) 11:18401. https://doi.org/10.1038/s41598-021-97651-3

911. Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Lih Kuo, Satoru Yamagami & Taiji Nagaoka. Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy. Nature Scientific Reports (2020) 10:19796. https://doi.org/10.1038/s41598-020-75296-y

910. Zhang A.J. and Wu S.M. (2021). Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells. Vision Research, May 15;186;13-22. PMID: 34004350.

909. Pang J.J., Gao, F. and Wu, S.M. (2021). Generators of pressure-evoked currents in vertebrate outer retinal neurons. Cells, 10, 1288. PMID: 34067375.

908. Pang J.J. and Wu, S.M. (2021). Ocular Pressure-Volume Relationship and Ganglion Cell Death in Glaucoma. OBM Neurobiology, 5 (2). PMID: 34308265.

907. Pang J.J., Gao, F. and Wu, S.M. (2021) Dual-cell patch-clamp recording revealed a mechanism for a ribbon synapse to process both digital and analog imputs and outputs. Frontiers in Cellular Neuroscience. Vol 15, 722533.

906. Yonju Ha, Lorenzo F Ochoa, Olivia Solomon, Shuizhen Shi, Paula P Villarreal, Shengguo Li, Seth Buscho, Gracie Vargas, Wenbo Zhang. Light-Sheet Microscopy of the Optic Nerve Reveals Axonal Degeneration and Microglial Activation in NMDA-Induced Retinal Injury. EC Ophthalmology 11 (2021):23-31.

905. Rong Xu, Yekai Wang and Jianhai Du (2021). Tracing Nitrogen Metabolism in Mouse Tissues with Gas Chromatography-Mass Spectrometry. Bioprotocol 11 (4): e3925. DOI: 10.21769/BioProtoc.3925.

904. Rui Zhang, Abbi L. Engel, Yekai Wang, Bo Li, Weiyong Shen, Mark C. Gillies, Jennifer R. Chao, and Jianhai Du. Inhibition of Mitochondrial Respiration Impairs Nutrient Consumption and Metabolite Transport in Human Retinal Pigment Epithelium. J. Proteome Res. 2021, 20, 909−922.

903. Jianhai Du, Siyan Zhu, Rayne R. Lim, Jennifer R. Chao. Proline metabolism and transport in retinal health and disease. Amino Acids https://doi.org/10.1007/s00726-021-02981-1.

902. Heidi M. Schmidt, Katherine C. Wood, Sara E. Lewis, Scott A. Hahn, Xena M. Williams, Brenda McMahon, Jeffrey J. Baust, Shuai Yuan , Timothy N. Bachman, Yekai Wang, Joo-Yeun Oh, Samit Ghosh , Solomon F. Ofori-Acquah,  Jeffrey D. Lebensburger, Rakesh P. Patel, Jianhai Du, Dario A. Vitturi , Eric E. Kelley, Adam C. Straub. Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease. Arterioscler Thromb Vasc Biol. 2021;41:769–782. DOI: 10.1161/ATVBAHA.120.315081 February 2021.

901. Rui Zhang, Weiyong Shen, Jianhai Du, and Mark C. Gillies. Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling. Cell Death and Disease (2020) 11:885 https://doi.org/10.1038/s41419-020-03103-7

900. Ian C Han, Erin R Burnight, Emily E Kaalberg , Timothy M Boyce , Edwin M Stone , John H Fingert, Robert F Mullins, Budd A Tucker, Luke A Wiley. Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants. J Ocul Pharmacol Ther. (2021) Oct 1. Online ahead of print; PMID: 34597181; DOI: 10.1089/jop.2021.0057 ; https://pubmed.ncbi.nlm.nih.gov/34597181/

899. Yi Li, Shuizhen Shi, Fan Xia, Chao Shan, Yonju Ha, Jing Zou, Awadalkareem Adam, Ming Zhang, Tian Wang, Hua Liu1, Pei‑Yong Shi, and Wenbo Zhang.  Zika virus induces neuronal and vascular degeneration in developing mouse retina. Acta Neuropathol Commun (2021) 9:97; doi.org/10.1186/s40478-021-01195-6

898. Sharif AS, Gerstner CD, Cady MA, Arshavsky V, Mitchell CA, Ying G, Frederick JM, Baehr W (2020). Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis. J. Biol. Chem., 2021 Mar 10; 296 100529;  doi.org/10.1016/j.jbc.2021.100529

897. Fan Xia, Yonju Ha, Shuizhen Shi, Yi Li, Shengguo Li, Jonathan Luisi, Rakez Kayed, Massoud Motamedi, Hua Liu, and Wenbo Zhang. Early alterations of neurovascular unit in the retina in mouse models of tauopathy. Acta Neuropathol Commun (2021) 9:51; doi.org/10.1186/s40478-021-01149-y

896. Monica M. Sautera, Curtis R. Brandt. Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells.  Experimental Eye Research, Volume 204, March 2021, 108436;  doi.org/10.1016/j.exer.2021.108436

2020 Publications

895. Cherry TJ, Yang MG, Harmin DA, Tao P, Timms AE, Bauwens M, Allikmets R, Jones EM, Chen R, De Baere E, Greenberg ME. Mapping the cis-regulatory Architecture of the Human Retina Reveals Noncoding Genetic Variation in Disease Proc Natl Acad Sci USA. 2020 Apr 21;117(16):9001-9012 PMID: 32265282 PMCID: PMC7183164

894. Wang J, Liu H, Bertrand RE, Sarrion-Perdigones A, Gonzalez Y, Venken KJT, Chen R. A novel statistical method for interpreting the pathogenicity of rare variants. Genet Med. 2021 Jan;23(1):59-68. doi: 10.1038/s41436-020-00948-3. Epub 2020 Sep 4. PMID: 32884132; PMCID: PMC7796914.

893. Bertrand RE, Wang J, Xiong KH, Thangavel C, Qian X, Ba-Abbad R, Liang Q, Simões RT, Sampaio SAM, Carss KJ, Lucy Raymond F, Robson AG, Webster AR, Arno G, Porto FBO, Chen R. Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy. Genet Med. 2020 Oct 20. doi: 10.1038/s41436-020-01003-x. Epub ahead of print. PMID: 33077892.

892. Diwa Koirala, Sarka Beranova-Giorgianni, Francesco Giorgianni. Early Transcriptomic Response to OxLDL in Human 2 Retinal Pigment Epithelial Cells. Int. J. Mol. Sci. 2020, 21(22), 8818; doi.org/10.3390/ijms21228818

891. Shi L, Zhao M, Abbey CA, Tsai SH, Xie W, Pham D, Chapman S, Bayless KJ, Hein TW, Rosa RH Jr, Ko ML, Kuo L, Ko YP. A newly identified peptide, peptide Lv, promotes pathological angiogenesis. J Am Heart Assoc 8(22):e013673, 2019.

890. Hein TW, Omae T, Xu W, Yoshida A, Kuo L. Role of arginase in selective impairment of endotheliumdependent nitric oxide synthase-mediated dilation of retinal arterioles during early diabetes. Invest Ophthalmol Vis Sci 61(5):36, 2020.

889. Chen Y-L, Rosa RH Jr, Kuo L, Hein TW. Hyperglycemia augments endothelin-1-induced constriction of human retinal venules. Trans Vis Sci Tech 9(9):1, 2020.

888. Shetty T, Sishtla K, Park B, Repass M, Corson TW. 2020. Heme synthesis inhibition blocks angiogenesis via mitochondrial dysfunction. iScience, 23, 101391.

887.Pran Babu SPS, White D, Corson TW. 2020. Ferrochelatase regulates retinal neovascularization. FASEB J, 34, 12419–12435.

886.Shetty T, Corson TW. 2020. Mitochondrial heme synthesis enzymes as therapeutic targets in vascular diseases. Frontiers in Pharmacology, 11, 1015. (appended)

885.Corson TW, Sardar Pasha SPB, Shetty T, Mathew D, Sishtla K, Patwari N, Lambert-Cheatham NA, Bhatwadekar AD. Retinal phenotyping of ferrochelatase mutant mice. Accepted as oral presentation at ARVO 2020. Investigative Ophthalmology & Visual Science, 61: E-abstract 5129.

884. Sardar Pasha SPB, Corson TW. Ferrochelatase regulates retinal neovascularization. Accepted as oral presentation at ARVO 2020. Investigative Ophthalmology & Visual Science, 61: E-abstract 2370.

883. Lambert-Cheatham NA, Sardar Pasha SPB, Park B, Kwon S, Waller S, Lee B, Seo S-Y, Corson TW. A novel ferrochelatase inhibitor decreases murine laser-induced choroidal neovascularization. Accepted as oral presentation at ARVO 2020. Investigative Ophthalmology & Visual Science, 61: E-abstract 3978.

882. Liu A, Ildefonso CJ, Bond WS, Hurwitz MY, Hurwitz RL. Inhibitors of metalloprotease, γsectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication. PLoS ONE 15(7): e0236175. doi.org/10.1371/journal.pone.0236175

881. Shurygina MF, Parker MA, Schlechter CL, Chen R, Li Y, Weleber RG, Yang P, Pennesi ME. A Case Report of Two Siblings With Alstrom Syndrome Without Hearing Loss Associated With Two New ALMS1 Variants. BMC Ophthalmol. 2019 Dec 7;19(1):246.  PMID: 31810438 PMCID: PMC6898930

880. Zou X, Fu Q, Fang S, Li H, Ge Z, Yang L, Xu M, Sun Z, Li H, Li Y, Dong F, Chen R, Sui R. Phenotypic variability of recessive RDH12-associated retinal dystrophy Retina 2019 Oct;39(10):2040-2052 PMID: 30134391

879.Fasham J, Arno G, Lin S, Xu M, Carss KJ, Hull S, Lane A, Robson AG, Wenger O, Self JE, Harlalka GV, Salter CG, Schema L, Moss TJ, Cheetham ME, Moore AT, Raymond FL, Chen R, Baple EL, Webster AR, Crosby AH; NIHR Bioresource Rare Diseases Consortium.  Delineating the expanding phenotype associated with SCAPER gene mutation.  Am J Med Genet A. 2019 Aug;179(8):1665-1671   PMID: 31192531

878. Qingnan Liang, Rachayata Dharmat, Leah Owen, Akbar Shakoor, Yumei Li, Sangbae Kim, Albert Vitale, Ivana Kim, Denise Morgan, Shaoheng Liang, Nathaniel Wu, Ken Chen, Margaret M. DeAngelis, Rui Chen Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling. Nature Communications 10, 5743 (2019) PMID: 31848347 PMCID: PMC6917696

877.Frederick JM, Hanke-Gogokhia C, Ying G, Baehr W. Diffuse or hitch a ride: how photoreceptor lipidated proteins get from here to there. Biol Chem. 2020 Apr 28;401(5):573-584. doi: 10.1515/hsz-2019-0375. PMID: 31811799 Review.

876. Baehr W, Hanke-Gogokhia C, Sharif A, Reed M, Dahl T, Frederick JM, Ying G. Insights into photoreceptor ciliogenesis revealed by animal models. Prog Ret.Eye Res. 2019 Jul;71:26-56. doi: 10.1016/j.preteyeres.2018.12.004. Epub 2018 Dec 25. PMID: 30590118 Free PMC article. Review

875. Seilheimer R.L., Sabharwal J. and Wu S.M. (2020) Genetic dissection of rod and cone pathways mediating light responses and receptive fields of ganglion cells in the mouse retina. Vision Research, 167, 15-23. PMID: 31887538. PMC7264069

874. Long Y., Seilheimer R.L. and Wu S.M. (2020) Glycinergic and GABAergic interneurons shift the location and differentially alter the size of ganglion cell receptive field centers in the mammalian retina. Vision Research, 170, 18-24. PMID: 32217368. PMC7872144

873. Tao X, Sabharwal J, Seilheimer RL, Wu SM, Frankfort BJ. (2020) Intraocular Pressure Elevation Compromises Retinal Ganglion Cell Light Adaptation. Invest Ophthalmol Vis Sci. 2020 Oct 1;61(12):15. PMID: 33064129. PMC7571289

872. Xu L, Brown EE, Keuthan CJ, Gubbi H, Swaroop A, Grellier EK, Roger JE, Du J, Ash JD. AMP-activated-kinase (AMPK) is essential sensor and metabolic regulator of retinal neurons and their integrated metabolism with RPE. bioRxiv 2020.05.22.109165; doi: https://doi.org/10.1101/2020.05.22.109165.

871. Li B,  Zhang T, Liu W, Wang Y, Xu R, Zeng S, Zhang R, Zhu S, Gillies MC, Zhu L, Du J. Metabolic features of mouse and human retinas: rods vs. cones, macula vs. periphery, retina vs. RPE. iScience. 2020

870. Zhang R, Shen W, Du J, Gillies MC. Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling. Cell Death & Disease. 2020

869. Rong Xu, Brianna K. Ritz, Yekai Wang, Jiancheng Huang, Chen Zhao, Kaizheng Gong, Xinnong Liu, and X Jianhai Du(2020); The retina and retinal pigment epithelium differ in nitrogen metabolism and are metabolically connected Biol.Chem.(2020)295(8)2324–2335 Received for publication,October 31,2019,and in revised form,January15,2020 Published, Papers in Press, January 17, 2020, DOI10.1074/jbc.RA119.011727

868. Rui Zhang, Abbi L. Engel, Yekai Wang, Bo Li, Weiyong Shen, Mark C. Gillies, Jennifer R. Chao,* and Jianhai Du (2020); Inhibition of Mitochondrial Respiration Impairs Nutrient Consumption and Metabolite Transport in Human Retinal Pigment Epithelium  https://dx.doi.org/10.1021/acs.jproteome.0c00690

867. Jiancheng Huanga, Jamie Schaeferc, Yekai Wangc,d, Lauren Gioiac, Ying Peif, Xiaofei Shif, Shanawar Warisc, Chen Zhaoa, John Nguyenc, Jianhai Du (2020), Metabolic signature of eyelid basal cell carcinoma, https://doi.org/10.1016/j.exer.2020.108140

866.  Zhu, L, Parker, M, Enemchukwa, N, Shen, M, Zhang, G, Yan, Q, Handa, JT, Fang, L, Fu, Y (2020).  Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice. Communications Biology 3, 386 (2020). https://doi.org/10.1038/s42003-020-1113-z.

865.  Xu H, Enemchukwu N, Zhong X, Zhang O, and Fu Y (2019). Deletion of M-opsin prevents “M cone” degeneration in a mouse model of Leber congenital amaurosis. American Journal of Pathology  Volume 190, ISSUE 5, P1059-1067. [Epub ahead of print] BioRxiv. doi: https://doi.org/10.1101/803510.

864.  Liu, H., Mei, F. C., Yang, W., Wang, H., Wong, E., Cai, J., Toth, E., Luo, P., Li, Y. M., Zhang, W. & Cheng, X., Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling, (Jan 1 2020).  Science Advances. 6, 1, eaay3566.

863.     Liu, W., Ha, Y., Xia, F., Zhu, S., Li, Y., Shi, S., Mei, F. C., Merkley, K., Vizzeri, G., Motamedi, M., Cheng, X., Liu, H. & Zhang, W., (2020).  Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension.  Journal of Experimental Medicine. 217, 4, e20190930.

2019 Publications

862.     MichelleYam, AbbiL.Engel, YekaiWang, SiyanZhu, AllisonHauer, RuiZhang, DanielLohner, JianchengHuang, MarleeDinterman, ChenZhao, JenniferR.Chao,and Jianhai Du (2019) Proline mediates metabolic communication between retinal pigment epithelial cells and the retina. The Journal of biological chemistry 294(26):10278-10289.

861.     Baehr W, Hanke-Gogokhia C, Sharif AS, Reed M, Dahl T, Frederick JM, Ying G (2019). Insights into Photoreceptor Ciliogenesis Revealed by Animal Models. Progr. Ret Eye Res, 71, 26-56. doi: 10.1016/j.preteyeres.2018.12.004. [Epub ahead of print] Review. PMID: 30590118; PMCID PMC6707082.

860.     Hanke-Gogokhia C, Chiodo VA, Hauswirth WW, Frederick JM, Baehr W (2018). Rescue of cone function in cone-only Nphp5 knockout mouse model with Leber congenital amaurosis phenotype. Molecular Vision 24:834-846. PMID:30713422 PMCID:PMC6334983.

859.     Schwikkard SL, Whitmore H, Sulaiman RS, Sishtla K, Shetty T, Basavarajappa HD, Waller C, Alqahtani A, Frankemoelle L, Chapman A, Crouch N, Wetschnig W, Knirsh W, Andriantiana J, Mas-Claret E, Langat MK, Mulholland DA*, Corson TW*. 2019. The antiangiogenic activity of naturally-occurring and synthetic homoisoflavonoids from the Hyacinthaceae (sensu APGII). Journal of Natural Products, 82, 1227–1239. *equal contributors. (appended)

858.     Seo SY, Corson TW. Small molecule target identification using photo-affinity chromatography. 2019. Methods in Enzymology, 622, 347–374. (appended).

857.     Heo M, Lee B, Sishtla K, Fei X, Lee S, Park S, Yuan Y, Lee S, Kwon S-I, Lee J, Kim S, Corson TW*, Seo S-Y*. 2019. Enantioselective synthesis of homoisoflavanones by asymmetric transfer hydrogenation and their biological evaluation for antiangiogenic activity. Journal of Organic Chemistry, doi: 10.1021/acs.joc.9b01134. *equal contributors. (appended)

856.     Park B, Corson TW. 2019. Soluble epoxide hydrolase inhibition for ocular diseases: vision for the future. Frontiers in Pharmacology, 10, 95. (appended)

855.     Yen-Lin Chen,1 Wenjuan Xu,1 Robert H. Rosa Jr.,1,2 Lih Kuo,1,2 and Travis W. Hein1,2, investigations on “Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-mode Sodium-Calcium Exchanger” was published in Diabetes (68:1624-1634, 2019).

854.     Yen-Lin Chen,1 Yi Ren,1 Wenjuan Xu,1 Robert H. Rosa Jr,1,2 Lih Kuo,1,2 and Travis W. Hein1,2, “Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase” was published in Investigative Ophthalmology & Visual Science in late December 2018 (59:5167-5175, 2018).

853.     Liu W, Xia F, Ha Y, Zhu S, Li Y, Folorunso O, Pashaei-Marandi A, Lin PY, Pierce AP, Liu H, Zhang W. Neuroprotective effects of HSF1 in retinal ischemia-reperfusion injury (2019). Invest Ophthalmol Vis Sci. 60(4):965-977.

852.     Moshiri A, Chen R, Kim S, Harris RA, Li Y, Raveendran M, Davis S, Liang Q, Pomerantz O, Wang J, Garzel L, Cameron A, Yiu G, Stout JT, Huang Y, Murphy CJ, Roberts J, Gopalakrishna KN, Boyd K, Artemyev NO, Rogers J, Thomasy SM. A nonhuman primate model of inherited retinal disease. J Clin Invest. 2019 Feb 1;129(2):863-874. doi: 10.1172/JCI123980. Epub 2019 Jan 22.

851.     Kim S, Lowe A, Dharmat R, Lee S, Owen LA, Wang J, Shakoor A, Li Y, Morgan DJ, Hejazi AA, Cvekl A, DeAngelis MM, Zhou ZJ, Chen R, Liu W. Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10824-10833.

850.     Park YH, Snook JD, Ostrin EJ, Kim S, Chen R, Frankfort BJ. Transcriptomic profiles of retinal ganglion cells are defined by the magnitude of intraocular pressure elevation in adult mice. Sci Rep. 2019 Feb 22;9(1):2594. doi: 10.1038/s41598-019-39141-1  PMID: 30796289.

849.     Wang J, Zhao L, Wang X, Chen Y, Xu M, Soens ZT, Ge Z, Wang PR, Wang F, Chen R GRIPT: a novel case-control analysis method for Mendelian disease gene discovery. Genome Biol. 2018 Nov 26;19(1):203. doi: 10.1186/s13059-018-1579-x.

848.     Chen C.A., Wang W., Pedersen S.E., Raman A., Seymour M.L., Ruiz F.R., Xia A., van der Heijden M.E., Wang L., Yin J., Lopez J., Rech M.E., Lewis R.A., Wu S.M., Liu Z., Pereira F.A., Pautler R.G., Zoghbi H.Y. and Schaaf C.P. (2019) Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. Hum Mol Genet. 2019 Oct 10. doi: 0.1093/hmg/ddz233. PMID: 31600777.

847.     Gao, F. Yang, Z., Jacoby, R., Wu, S.M. and Pang J.J. (2019) The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. Cell Death Dis. 2019 May 7;10(5):364. doi: 10.1038/s41419-019-1576-3. PMID: 31064977.

846.    Tao X, Sabharwal J, Seilheimer RL, Wu SM, Frankfort BJ. (2019) Mild Intraocular Pressure Elevation in mice reveals distinct retinal ganglion cell functional thresholds and pressure-dependent properties. J. Neuroscience. 6;39(10):1881-1891. PMID: 30622167.

2018 Publications

845. Pang JJ, Yang Z, Jacoby RA, Wu SM. (2018) Cone synapses in mammalian retinal rod bipolar cells. J Comp Neurol. 2018 Apr 18. PMID: 29667170

844. Shen G, Link S, Kumar S, Nusbaum DM, Tse DY, Fu Y, Wu SM, Frankfort BJ. (2018) Characterization of retinal ganglion cell and optic nerve phenotypes caused by sustained intracranial pressure elevation in mice. Scientific Reports, 8(1): 2856. PMID: 29434244.

843. Lotfi P., Tse D.Y., Di Ronza A., Seymour M.L., Martano G., Cooper J.D., Pereira F.A., Passafaro M., Wu S.M., Sardiello M. (2018). Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy. 2018 Jul 23:1-16. doi: 10.1080/15548627. 2018. 1474313. PMID: 29916295.

842. Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. J Cell Biol. 2018 Aug 6;217(8):2851-2865. doi: 10.1083/jcb.201712117. Epub 2018 Jun 13. PMID: 29899041.

841. Zaneveld SA, Eblimit A, Liang Q, Bertrand R, Wu N, Liu H, Nguyen Q, Zaneveld J, Wang K, Li Y, Chen R. Gene Therapy Rescues Retinal Degeneration in Reep6 Mutant Mice. Hum Gene Ther. 2018 Aug 13. doi: 10.1089/hum.2018.078.

840. Eblimit A, Zaneveld SA, Liu W, Thomas K, Wang K, Li Y, Mardon G, Chen R. NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype. Exp Eye Res. 2018 Apr 17;173:32-43.

839. Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Mardon G, Chen R. Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice.  Exp Eye Res. 2018 Jan;166:120-130.  PMID: 29100828.

838. DuPont M, Jones EM, Xu M, Chen R. Investigating the disease association of USH2A p.C759F variant by leveraging large retinitis pigmentosa cohort data. Ophthalmic Genet. 2018 Apr;39(2):291-292.  PMID: 29283788.

837.Zhang L, Sun Z, Zhao P, Huang L, Xu M, Yang Y, Chen X, Lu F, Zhang X, Wang H, Zhang S, Liu W, Jiang Z, Ma S, Chen R, Zhao C, Yang Z, Sui R, Zhu X. Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa. Hum Mol Genet. 2018 Jul 31. PMID: 30101608.

836. Zhou Q, Yao F, Wang F, Li H, Chen R, Sui R. A heterozygous mutation in RPGR associated with Xlinked retinitis pigmentosa in a patient with Turner syndrome mosaicism (45,X/46,XX). Am J Med Genet A. 2018 Jan;176(1):214-218

835. Zhao M, Xie W, Tsai S-H, Hein TW, Rocke BA, Kuo L, Rosa RH Jr. Intravitreal stanniocalcin-1 enhances new blood vessel growth in a rat model of laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci 59:1125-1133, 2018.

834. Tsai S-H, Xie W, Zhao M, Rosa RH Jr, Hein TW, Kuo L. Alterations of ocular hemodynamics impair ophthalmic vascular and neuroretinal function. Am J Pathol 188:818-827, 2018.

833. Ha Y*, Liu W*, Liu H, Zhu S, Xia F, Gerson JE, Azhar NA, Tilton RG, Motamedi M, Kayed R, Zhang W. AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by down-regulating ER stress and tau oligomer formation (2018). Invest Ophthalmol Vis Sci. 2018 59:4670-4682. (RRF support is cited)

832. Sauter, MS, Kolb, AW and Brandt, CR. Toll-like receptors 4 ,5, 6, and 7 are constitutively expressed in non-human primate retinal neurons. J Neuroimmunology 322:26-35, 2018.

831.Sulaiman, R. S., Park, B., Sheik Pran Babu, S. P., Si, Y., Kharwadkar, R., Mitter, S. K., Lee, B., Sun, W., Qi, X., Boulton, M. E., Meroueh, S. O., Fei, X., Seo, S. Y. & Corson, T. W. Chemical proteomics reveals soluble epoxide hydrolase as a therapeutic target for ocular neovascularization. ACS Chem Biol 13, 45-52, (2018). PMCID: PMC5775043.

830. Sardar Pasha SPB*, Sishtla K*, Sulaiman RS, Park B, Shetty T, Shah F, Fishel M, Wikel JH, Kelley MR, Corson TW. Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization. 2018. Journal of Pharmacology and Experimental Therapeutics, 367, 108–118. *equal contributors. (appended)

829. Hanke-Gogokhia C, Wu Z, Sharif A, Yazigi H, Frederick JM, Baehr W (2017). The guanine nucleotide exchange factor, Arf-like protein 13b, is essential for assembly of the mouse photoreceptor transition zone and outer segment. J Biol Chem, Dec 29;292(52):21442-21456. PMID: 29089384. PMCID: PMC5766971.

2017 Publications

828. Sabharwal J. Seilheimer R. Cowan, C.S., and Wu, S.M. (2016) The ON crossover circuitry shapes spatiotemporal profile in the center and surround of mouse OFF retinal ganglion cells. Frontiers in Neural Circuits, 10, article 106, 1-10.

827. Sabharwal J. Cowan, C.S., Seilheimer R. and Wu, S.M. (2017) Distinct subcomponents of mouse retinal ganglion cell receptive fields are differentially altered by light adaptation. Vision Research, 131, 96-105.

826. Palmieri M, Pal R, Nelvagal H, Lotfi P, Stinnett G, Seymour M, Chaudhury A, Bajaj L, Bondar V, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson J, Pereira F, Pautler R, Rodney G, Cooper J, and Sardiello M (2017) mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nature Communications, 8: 14388, DOI: 10.1038/ncomms14388.

825. Sabharwal, J., Seilheimer, R. L., Tao, X, Cowan, C.S., Frankfort, B. J. and Wu, S.M. (2017) Elevated IOP alters the space–time profiles in the center and surround of both ON and OFF RGCs in mouse. Proc. Nat. Acad. Scien. (USA), August 15, 114, 33, 8859-8864.

824. Tse D.Y., Kim S.J., Chung I., He F., Wensel T.G., Wu S.M. (2017) The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int. J. Ophthalmol. 2017 Sep 18;10(9):1361-1369.

823. Arno G, Agrawal SA, Eblimit A, Bellingham J, Xu M, Wang F, Chakarova C, Parfitt DA, Lane A, Burgoyne T, Hull S, Carss KJ, Fiorentino A, Hayes MJ, Munro PM, Nicols R, Pontikos N, Holder GE; UKIRDC., Asomugha C, Raymond FL, Moore AT, Plagnol V, Michaelides M, Hardcastle AJ, Li Y, Cukras C, Webster AR, Cheetham ME, Chen R. Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa. Am J Hum Genet. 2016 Dec 1;99(6):1305-1315. doi: 10.1016/j.ajhg.2016.10.008. PMID: 27889058

822. Dharmat R, Liu W, Ge Z, Sun Z, Yang L, Li Y, Wang K, Thomas K, Sui R, Chen R. IFT81 as a Candidate Gene for Nonsyndromic Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2483-2490 PMID: 28460050 PMCID: PMC5413215

821. Xu M, Xie YA, Abouzeid H, Gordon CT, Fiorentino A, Sun Z, Lehman A, Osman IS, Dharmat R, Riveiro-Alvarez R, Bapst-Wicht L, Babino D, Arno G, Busetto V, Zhao L, Li H, Lopez-Martinez MA, Azevedo LF, Hubert L, Pontikos N, Eblimit A1, Lorda-Sanchez , Kheir V, Plagnol V, Oufadem M, Soens ZT1, Yang L, Bole-Feysot C, Pfundt R, Allaman-Pillet N, Nitschké P, Cheetham ME, Lyonnet S, Agrawal SA, Li H, Pinton G, Michaelides M, Besmond C, Li Y, Yuan Z, von Lintig J, Webster AR, Le Hir H, Stoilov P; UK Inherited Retinal Dystrophy Consortium, Amiel J, Hardcastle AJ, Ayuso C, Sui R, Chen R (co corresponding), Allikmets R, Schorderet DF Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies. Am J Hum Genet. 2017 Apr 6;100(4):592-604 PMID: 28285769 PMCID: PMC5384039

820. Akinfenwa, P.Y., Bond, W.S., Ildefonso, C.J., Hurwitz, M.Y., Hurwitz, R.L. Versican G1 Domain Enhances Adenoviral-Mediated Transgene Expression and Can Be Modulated by Inhibitors of the Janus Kinase (JAK)/STAT and Src Family Kinase Pathways. J. Biol. Chem. 292(35), 14381-14390, 2017. ePublished ahead of print July 6, 2017 PMID: 28684419.

819. Mlotshwa, B.C., Mwesigwa, S., Mboowa, G., Williams, L., Retshabile, G., Kekitiinwa, A., Wayengera, M., Kyobe, S., Brown, C.W., Hanchard, N.A., Mardon, G., Joloba, M., Anabwani, G., and Mpoloka, S.W. (2017). The collaborative African genomics network training program: a trainee perspective on training the next generation of African scientists. Genet Med. 2017 Jul;19(7):826-833. PMID: 28383545. PMCID: PMC5509501. (no reprint available yet)

818. Zhu S*, Luo H*, Liu H, Ha Y, Mays ER, Lawrence RE, Winkelmann E, Barrett AD, Smith SB, Wang M, Wang T#, Zhang W#. p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection (2017). Antiviral Res. 145:70-81.

817. Liu W*, Luisi J*, Liu H, Motamedi M#, Zhang W#. OCT-Angiography for non-invasive monitoring of neuronal and vascular structure in mouse retina: Implication for characterization of retinal neurovascular coupling (2017). EC Ophthalmology. 5.3: 89-98. (This article was selected as “Best article of the Issue”).

816. Zhu S, Liu H, Sha H, Qi L, Gao DS#, Zhang W#. PERK and XBP1 differentially regulate CXCL10 and CCL2 production (2017). Experimental Eye Research. 155: 1-14.

815. Ha Y, Liu H, Zhu S, Yi P, Liu W, Nathanson J, Loucas B, Sun J, Frishman LJ, Motamedi M, Zhang W#. Critical Role for the CXCL10/CXCR3 Axis in Leukocyte Recruitment and Neuronal Injury in Traumatic Optic Neuropathy induced by Optic Nerve Crush (2017). Am J Pathol. 187(2):352-365. (This article was listed as “an Editor’s Choice article” and was also reported as news by Science Daily).

814. Otani S, Nagaoka T, Omae T, Tanano I, Kamiya T, Ono S, Hein TW, Kuo L, Yoshida A. Histamine-induced dilation of isolated porcine retinal arterioles: Role of endothelium-derived hyperpolarizing factor. Invest Ophthalmol Vis Sci 57:4791-82016, 2016.

813. Zhao M, Xie W, Tsai SH, Hein TW, Rocke RA, Kuo L*, Rosa, RH Jr*. Intravitreal stanniocalcin-1 enhances new blood vessel growth in a rat model of laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci 2017 (under review) *Co-correspondance

812. Basavarajappa HD, Sulaiman RS, Qi X, Shetty T, Pran Babu SS, Sishtla KL, Lee B, Quigley J, Alkhairy S, Briggs CM, Gupta K, Tang B, Shadmand M, Grant MB, Boulton ME, Seo SY, Corson TW. 2017. Ferrochelatase is a therapeutic target for ocular neovascularization. EMBO Molecular Medicine, e201606561. Comment by Gough NR, BioSerendipity, 10 July 2017.

811. Christin Hanke-Gogokhiaa, Zhijian Wub, Ali Sharifa, Hussein Yazigia, Jeanne M. Fredericka, Wolfgang Baehr, Arf-like Protein 13b (ARL13b), the ARL3 GEF, regulates assembly of the mouse photoreceptor transition zone and outer segment, Journal of Biological Chemistry (accepted, no reprint available yet)

 2016 Publications

810. Cowan CS, Sabharwal J, Wu SM. (2016) Space-time codependence of retinal ganglion cells can be explained by novel and separable components of their receptive fields. Physiol Rep. 2016 Sep; 4(17). pii: e12952.

809. van der Heijden ME, Shah P, Cowan CS, Yang Z, Wu SM, Frankfort BJ. Effects of Chronic and Acute Intraocular Pressure Elevation on Scotopic and Phototopic Contrast Sensitivity in Mice. Invest Ophthalmol Vis Sci. 2016 Jun 1; 57(7):3077-87.

808. He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG. (2016) Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Report. 2016 Jun 1; 6:26978.

807. Want J, Jacoby R, Wu SM. (2016) Physiological and morphological characterization of ganglion cells in the salamander retina. Vision Res. 2016 Feb; 119:60-72.

806. Cowan CS, Abd-El-Barr M, van der Heijden M, Lo EM, Paul D, Bramblett DE, Lem J, Simons DL, Wu SM. (2016) Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. Vision Res. Feb; 119:99-109.

805. Soens ZT, Li Y, Zhao L, Eblimit A, Dharmat R, Li Y, Chen Y, Naqeeb M, Fajardo N, Lopez I, Sun Z, Koenekoop RK, Chen R. Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Genetics in medicine. 2016 Jan 28;PMID:26820066 PMCID: PMC4965339.

804. Fu Q, Xu M, Chen X, Sheng X, Yuan Z, Liu Y, Li H, Sun Z, Li H, Yang L, Wang K, Zhang F, Li Y, Zhao C, Sui R, Chen R. CEP78 is mutates in a distinct type of Usher syndrome. J Med Genet. 2016 Sept 14. pii: jmedgenet-2016-104166. doi: 10.1136/jmedgenet-2016-104166. [Epub ahead of print] PMID: 27627988, PMCID: Pending.

803. Kuang, S.Q., O. Medina-Martinez, D. C. Guo, L. Gong, E.S. Regalado, C.L. Reynolds, C. Boileau, G. Jondeau, S. K. Prakash, C.S. Kwartler, L. Y. Zhu, A.M. Peters, X.Y. Duan, GenTAC Investigators, National Heart, Lung and Blod Institute Go Exome Sequencing Project, M. J. Bamshad, J. Shendure, D.A. Nickerson, R.L. Santos-Cortez, X.R. Dong, S.M. Leal, M. W. Majesky, E.C. Swindell, Jamrich, M., Milewicz, D.M. (2016). FOXE3 Mutations Predispose to Thoracic Aortic Aneurysms and Dissections; Foxe3 Deficiency in Mice Leads to Smooth Muscle Apoptosis and Aortic Rupture. J. Clin Invest. 126(3):948-61. PMID: 26854927.

802. Gersztenkorn D, Coletta C, Zhu S, Ha Y, Liu H, Tie H, Zhou J, Szabo C, Zhang W, Motamedi M. Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3002-9. doi: 10.1167/iovs.15-18555.

801. Hein TW, Xu W, Xu X, Kuo L. Acute and chronic hyperglycemia elicit JIP1?JNK-mediated endothelial vasodilator dysfunction of retinal arterioles. Invest Ophthalmol Vis Sci 57(10):4333-4340, 2016.

800. Sauter MM, Brandt CR. Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis, Experimental Eye Research. 148 (2016) 12-23.

799. Lee B, Sun W, Lee H, Basavarajappa HD, Sulaiman RS, Sishtla K, Fei X, Corson TW, Seo SY. 2016. Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids. Bioorganic & Medicinal Chemistry Letters, 26, 4277-4281. (appended).

798. Lee H, Yuan Y, Rhee I, Corson TW, Seo SY. 2016. Synthesis of natural homoisoflavonoids having either 5,7-dihydroxy-6-methoxy or 7-hydroxy-5,6-dimethoxy groups. Molecules, 21, 1058. (appended).

797. Sulaiman RS, Merrigan S, Quigley J, Boulton ME, Kennedy B, Seo SY, Corson TW. 2016. A small molecule pharmacotherapy ameliorates ocular neovascularization without toxicity. Scientific Reports, 6, 25509. (appended).

796. Hanke-Gogokhia C, Wu Z, Gerstner CD, Frederick JM, Zhang H, Baehr W (2016). Arf-like protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors. J Biol Chem, 291, 7142-7155. PMID: 26814127. PMCID: PMC4807295.

795. Rao KN, Zhang W, Li L¹, Ronquillo C, Li T, Baehr W, and Khanna H (2016). Ciliopathy-associated protein CEP290 modified the severity of retinal degeneration due to loss of RPGR. Hum Mol Genet. 2016 Mar 2. pii: ddw075. [Epub ahead of print]. PMID:26936822.

794. Ronquillo CC, Hanke-Gorokhia C, Revelo PM, Frederick JM, Li Jiang, Baehr W (2016). The Nphp5^-/- mouse: a model for Leber Congenital Amaurosis. FASEB J. 2016 Jun 21. pii: fj.201600511R. [Epub ahead of print]

2015 Publications

793. Eblimiti, A., Xu, H., Nguyen, T.T., Chen, Y., Esteve-Ruud, J., Zhong, H., Lettebore, S., van Reeuwijk, J., Simons, D.L., Ding, Q., Wu, K.M., Li, Y., van Beersum, S., Y., Xu, H., Pickard, P., Wang, K., Gan, L., Wu S.M., Williams, D.S., Mardon, G., Roepman, R., and Chen, R. (2014) Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina. Human Molecular Genetics, 11, 1-18.

792. Khan, A.K., Tse, D.Y., van der Heijden, M., Shah, P., Nusbaum, D., Yang, Z., Wu S.M., and Frankfort, B.J. (2015) Prolonged elevation of intraocular pressure results in retinal ganglion cell loss and abnormal retinal function in mice. Experimental Eye Research, 130, 29-37.

791. Pang, J.J., Frankfort, B.J., Gross, R.L. and Wu, S.M. (2015) Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice. Proc. Nat. Acad. Scien. (USA), 112, 8, 2593-2598.

790. Nusbaum, D.M., Wu, S.M., Frankfort, B.J. (2015) Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice. Experimental Eye Research, 136, 38-44.

789. W.H. Xiong, J.J. Pang, M.E. Pennesi, M. Tekmen, R.M. Duvoisin, S.M. Wu, C. W. Morgans (2015) The effect of PKCα on the light response of rod bipolar cells in the mouse retina. Invest. Ophthalmol. Vis. Sci., 56(8): 4961-4974.

788. Hui Wang, Xia Wang, Xuan Zou, Shan Xu, Hui Li, Keqing Wang, Yumei Li, Fangtian Dong, Rui Chen, Ruifang Sui. Comprehensive molecular diagnosis of a large Chinese Leber congenital amaurosis cohort, IOVS, June 2015, Vol. 56, 3642-3655.

787. Xu M, Gelowani V, Eblimit A, Wang F, Young MP, Sawyer BL, Zhao L, Jenkins G, Creel DJ, Wang K, Ge Z, Wang H, Li Y, Hartnett ME, Chen R. ATF6 is Mutated in Early Onset Photoreceptor Degeneration with Macular Involvement, Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3889-95. doi: 10.1167/iovs.15-16778.

786. Xu, M, Yang L, Wang F, Li H, Wang X, Wang W, Ge Z, Wang K, Zhao L, Li H, Li Y, Sui R, Chen R. Mutations in human IFT140 cause non-syndromic retinal degeneration Hum Genet. 2015 Oct;134(10):1069-78. doi: 10.1007/s00439-015-1586-x. Epub2015 Jul 28.

785. Bankhead, E.J., Colasanto, M.P., Dyorich, K.M., Jamrich, M., Murtaugh, L.C., Fuhrmann, S. (2015). Multiple Requirements of the Focal Dermal Hypoplasia Gene Porcupine during Ocular Morphogenesis. Am J Pathol. 185:197-213.

784. Zhong, H, Chen Y, Li, Y, Chen, R, Mardon, G. CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes. Scientific Reports. 2015 Feb 10;5:8366 doi:10.1038/srep08366. PubMed PMID: 25666713

783. H Zhong, A Eblimit, Y Moayedi, SL Boye, VA Chiodo, Y Chen, Y Li, RM Nichols, WW Hauswirth, R Chen, G. Mardon. AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa. Gene Therapy. 2015 Aug;22(8):619-27. doi:10.1038/gt.2015.42.Epub 2015 May 12.

782. Gersztenkorn D, Coletta C, Zhu S, Ha Y, Liu H, Ding Y, Zhou J, Szabo C, Zhang, W, Motamedi M. The cystathionine gamma-lyase/hydrogen sulfide pathway is involved in pathological retinal neovascularization in ischemic retinopathy. Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4689. (ARVO meeting abstract)

781. Zhang W, Zhu S, Ali S, Martirossian AN, Hu X, Al-Enazy S, Albekairi N, Motamedi M, Rytting E. Nanoparticle-medicated delivery of hydrophobic compounds to retinal microvascular endothelial cells. Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4160. (ARVO meeting abstract)

780. Hein TW, Rosa RH Jr, Ren Y, Xu W, and Kuo L. VEGF receptor-2-linked PI3K/Calpain/SIRT1 activation mediates retinal arteriolar dilations to VEGF and shear stress. Invest Ophthalmol Vis Sci 56:5381-5389, 2015.

779. Singh R, Kuai D, Guziewicz KE, Meyer J, Wilson M, Lu J, Smith M, Clark E, Verhoeven A, Aguirre GD, Gamm, DM. Pharmacological modulation of photoreceptor outer segment degradation in a human iPS cell model of inherited macular degeneration. Mol Ther. 2015 Aug 24. (Epub ahead of print). PubMed PMID:26300224.

778. Basavarajappa HD, Lee B, Lee H, Sulaiman RS, An H, Magaña C, Shadmand M, Vayl A, Rajashekhar G, Kim E-Y, Suh Y-G, Lee K, Seo S-Y, Corson TW. 2015. Synthesis and biological evaluation of novel homoisoflavonoids for retinal neovascularization. Journal of Medicinal Chemistry, 58, 5015-5027.

777. Sulaiman RS, Quigley J, Qi X, O’Hare MN, Grant M, Boulton ME, Corson TW. 2015. A simple optical coherence tomography quantification method for choroidal neovascularization. Journal of Ocular Pharmacology and Therapeutics, 31, 447-54.

776. Cecinio C. Ronquillo CC, Li Jiang L, Hanke-Gogokhia C, Gerstner CD, Revelo MP, Jeanne M. Frederick JM and Baehr W (2015). The Nphp5^-/- mouse: a model for Leber Congenital Amaurosis. Submitted to Hum. Mol. Genetics.

775. Hanke-Gogokhia C, Wu Z, Frederick JM, Gerstner CD, Zhang H, Baehr W (2015). The function of ARL3 in photoreceptors. Submitted to eLife.

2014 Publications

774. Tse, D.Y., Chung I. and Wu S.M. (2014a) “Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.”  Vision Res., 103: 49-62.

773. Tse, D.Y., Chung I. and Wu S.M. (2014b) “Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses.” Vision Res., 103: 63-74.

772. Ressler, S.J., Dang, T.D., Wu, S.M., Tse, D.Y., Gilbert, B.E., Vyakarnam, A., Yang, F., Schauer, I.G., Barron, D.A. and Rowley, D.R. (2014) “WFDC1 is a Key Modulator of Inflammatory and Wound Repair Responses.” American J. of Pathology, 184,11: 2951-2964.

771. Wang F, Wang Y, Zhang B, Zhao L, Lyubasyuk V, Wang K, Xu M, Li Y, Wu F, Wen C, Bernstein PS, Lin D, Zhu S, Wang H, Zhang K, Chen R. “A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa.” Invest Ophthalmol Vis Sci. 2014 Oct 14. PMID: 25316723.

—(reported “in press” 2013)— Keeley PW, Luna G, Skyles KA, Madsen N, Raven MA, Poche RA, Behringer RR, Swindell EC, Jamrich M, Fisher SK and Reese BE (2014) “Development and Plasticity of Outer Retinal Circuitry Following Genetic Removal of Horizontal Cells.” J. Neurosci. 33, 17847-62.

770. Sauter MM, Gauger JJ, Brandt CR. “Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps.” Antiviral Res. 109:83-96, 2014.

769. Luke B. Potts, Patrick D. Bradley, Wenjuan Xu, Lih Kuo, and Travis W. Hein. “Role of Endothelium in Vasomotor Responses to Endothelin System and Protein Kinase C Activation in Porcine Retinal Arterioles.” Invest. Ophthalmol. Vis. Sci. 54:7587-7594, 2013.

768. Sulaiman RS, Basavarajappa HD, Corson TW. 2014. “Natural product inhibitors of ocular angiogenesis.” Experimental Eye Research, DOI:10.1016/j.exer.2014.10.002.

767. Lee B, Basavarajappa HD, Sulaiman RS, Fei X, Seo S-Y, Corson TW. 2014. “First synthesis of the antiangiogenic homoisoflavanone, cremastranone.” Organic and Biomolecular Chemistry, 12, 7673-7677.

766. Basavarajappa HD, Lee B, Fei X, Lim D, Callaghan B, Mund JA, Case J, Rajashekhar G, Seo SY, Corson, TW. 2014. “Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.” PLoS ONE, 9, e95694.

765. Zhang M, Covar J, Zhang YN, Marshall B, Mo J, Atherton SS. “Virus spread and immune response following anterior chamber inoculation of HSV-1 lacking the Beclin-Binding Domain (BBD).” J. Neuroimmunol. 2013;260:82-91.

764. Mo J, Zhang M, Smith S, Marshall B, Atherton SS. “Interplay of autophagy and apoptosis during MCMV infection of RPE cells.” Molecular Vision. 2014;20:1161-1173.

763. Marshall B, Mo J, Covar J, Atherton SS, Zhang M. “Decrease of Murine Cytomegalovirus Induced Retinitis by Intravenous Delivery of Immediate Early Protein-3 Specific siRNA.” Invest. Ophthalmol. Vis. Sci. 2014;55:4151-7.

762. Mo J, Marshall B, Covar J, Smith SB, Atherton SS, Zhang M. “Role of Bax in death of uninfected retinal cells during murine cytomegalovirus (MCMV) retinitis.” Invest. Ophthalmol. Vis. Sci. 2014 Oct 8. pii: IOVS-14-15404. doi: 10.1167/iovs.14-15404.

2013 Publications

761. Frankfort B, Khan AK, Tse DY, Chung I, Pang JJ, Yang Z, Gross R, and Wu SM (2013) “Elevated intraocular pressure causes inner retinal dysfunction prior to cell loss in a mouse model of experimental glaucoma.” Invest. Ophthal. Vis. Scien., 54, 1: 762-770.

760. Pang JJ, Paul DL, and Wu SM (2013) “Survey on amacrine cell coupling to retrograde-identified ganglion cells in the mouse retina.” Invest. Ophthalmol. Vis. Sci. 1; 54: 5151-62.

759. Gao F, Pang JJ and Wu SM (2013) “Sign-preserving and sign-inverting rod-cone interactions in the salamander retina.” J. Physiology, 00, 1-16.

758. Qing Fu, Feng Wang, Hui Wang, Fei Xu, Jacques Zaneveld, Huanan Ren, Vafa Keser, Irma Lopez, Hang-Fang Tuan, Jason Salvo, Xia Wang, Li Zhao, Keqing Wang, Yumei Li, Robert Koenekoop, Rui Chen, Ruifang Sui “Next Generation Sequencing Based Molecular Diagnosis of a Chinese Patient Cohort with Autosomal Recessive Retinitis Pigmentosa.” IOVS, 2013 Jun 14;54(6):4158-66.

757. Wang X, Wang H, Sun V, Tuan HF, Keser V, Wang K, Ren H, Lopez I, Zaneveld JE, Siggiqui S, Bowles S, Khan A, Salvo J, Jacobson SG, Iannaccone A, Wang F, Birch D, Heckenlively JR, Fishman GA, Traboulsi EI, Li Y, Wheaton D, Koenekoop RK, Chen R “Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing.” J Med Genet. 2013 July 11 PMID: 23847139.

756. Wang F, Wang H, Tuan HF, Nguyen DH, Sun V, Keser V, Bowne SJ, Sullivan LS, Luo H, Zhao L, Wang X, Zaneveld JE, Salvo JS, Siddiqui S, Mao L, Wheaton DK, Birch DG, Branham KE, Heckenlively JR, Wen C, Flagg K, Ferreyra H, Pei J, Khan A, Ren H, Wang K, Lopez I, Qamar R, Zenteno JC, Ayala-Ramirez R, Buentello-Volante B, Fu Q, Simpson DA, Li Y, Sui R, Silvestri G, Daiger SP, Koenekoop RK, Zhang K, Chen R “Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements.” Hum Genet. 2013 Oct 24. [Epub ahead of print]

755. Bond WS, Akinfenwa PY, Perlaky L, Hurwitz, MY, Hurwitz, RL, Chévez-Barrios, P. “Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors are of Malignant Origin.” PLoS ONE 8(6): e63519. Doi:10.1371/journal.pone.0063519, 2013. PMID: 23658322.

754. Lu F, Kar D, Gruenig N, Cousins N, Rodgers H, Swindell E, Jamrich M, Schuurmans C, Mathers P, and Kurrasch D (2013) “Rax is a selector gene for the establishment of hypothalamic feeding circuits.” J. Neurosci. 33, 259-272.

753. Nasonkin IO, Merbs SL, Lazo K, Oliver V, Brooks M, Patel K, Enke RA, Nellissery J, Jamrich M, Le YZ, Bharti K, Rachel RA, Fariss RN, Zack DJ, Rodriguez-Boulan EJ, Swaroop A (2013) “Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a critical role of retinal pigment epithelium integrity in photoreceptor development.” Development 140, 1330.

752. Keeley PW, Luna G, Skyles KA, Madsen N, Raven MA, Poche RA, Behringer RR, Swindell EC, Jamrich M, Fisher SK and Reese BE (2014) “Development and Plasticity of Outer Retinal Circuitry Following Genetic Removal of Horizontal Cells.” J. Neurosci. (in press)

751. Atkins M, Jiang, Sansores-Garcia L, Jusiak B, Halder G, Mardon G (2013) “Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.” PLoS Genetics, Aug;9(8):e1003731. PMID: 24009524. PMCID: PMC3757064.

750. Jin M, Jusiak B, Bai Z, Mardon G (2013) “Eyes absent Tyrosine Phosphatase Activity is Not Required for Drosophila Development or Survival.” PLoS One, 8(3):e58818. PMCID: PMC3595212.

749. Haase-Gilbert E, Kwak SJ, Chen R, Mardon G (2013) “Drosophila signal peptidase complex member spase12 is required for normal development and cell differentiation.” PLoS One, 8(4):e60908. PMID: 23573290. PMC3616019.

748. Potts LB, Ren Y, LuG, Kuo E, Ngo E, Kuo L, Hein TW “Constriction of retinal arterioles to endothelin-1: requisite role of Rho kinase independent of protein kinase C and L-type calcium channels.” Invest Ophthalmol. Vis. Sci. 53:2904-2912, 2012.

747. Hein TW, Potts LB, Xu W, Yuan Z, Kuo L “Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes.” Invest. Ophthalmol. Vis. Sci. 53: 7943-7949, 2012.

2012 Publications

746. Price, B., Sandoval, I.M., Chan, F., Simons, D.L., Wu, S.M., Wensel, T.G. and Wilson, J.H. (2011) “Mislocalization and degradation of human P23H-rhodopsin-GFP in a knock-in mouse model of retinitis pigmentosa,” Invest. Ophthal. Vis. Scien., 52, 13, 9728-9736.

745. Pang, J.J., Gao, F. and Wu, S.M. (2012) “Physiological characterization and functional heterogeneity of narrow-field mammalian amacrine cells,” J. Physiology, 590, 1, 223-234.

744. Pang, J.J., Gao, F., Paul, D. L. and Wu, S.M. (2012) “Rod, M-cone and M/S-cone inputs to hyperpolarizing bipolar cells in the mouse retina,” J. Physiology, 590, 4, 845-854.

743. Pang, J.J., Gao, F. and Wu, S.M. (2012) “Ionotropic glutamate receptors mediate OFF responses in light-adapted depolarizing bipolar cells,” Vision Research, 68, 48-58.

742. Cho, SH, Kim JY, Simons DL, Song JY, Le JH, Swindell EC, Jamrich M, Wu SM, Kim S (2012) “Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis,” Hum Mol Genet. 21(12):2663-76.

741. B.J. Frankfort, A.K. Khan, D.Y. Tse, I. Chung, J.J. Pang, Z. Yang, R.L. Gross, and S.M. Wu, “Elevated intraocular pressure causes inner retinal dysfunction prior to cell loss in a mouse model of experimental glaucoma,” in review.

740. Hui Wang, Xianfeng Chen, Lynn Dudinsky, Claire Patenia, Yiyun Chen, Yumei Li, Yue Wei, Emad B. abboud, Ali A. Al-Rajhi, Richard Alan Lewis, James R. Lupski, Graeme Mardon, Richard A. Givvs, Brian D. Perkins, Rui Chen (2011) “Exome capture sequencing identifies a novel mutation in BBS4,” Molecular Vision 2011, 17:3529-40. PMID: 22219648.

739. Zhi D, Chen R (2012) “Statistical Guidance for Experimental Design and Data Analysis of Mutation Detection in Rare Monogenic Mendelian Diseases by Exome Sequencing.” PloS ONE 7(2):e31358. doi:10.1371/journal.pone.0031358

738. Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Naqeeb M, FORGE Canada Consortium, Leeds Study Group, Keser V, Mardon G, Xu H, Inglehearn CF, Fu Q, Toomes C, Chen R “Mutant NMNAT1 causes human blindness due to Leber congenital amaurosis: the elusive LCA9 gene.” Nature Genetics 2012, 44(9):1035-9.

737. Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, XU HP, Jamrich M, Itohara S, Feller MB and Crair MC (2012) “Role of adenylate cyclase 1 in retinofugal map development.” J. Comp. Neurol. 520, 1562-1583.

736. Wadhwa L, Bond WS, Perlaky L, Overbeek P, Hurwitz MY, Hurwitz RL, Chévez-Barrios P. “Embryonic Retinal Tumors in SV40-T-Ag Transgenic Mice Contain CD133+ Tumor-initiating Cells.” Invest. Ophthalmol. Vis Sci. 53, 3454-3462, 2012, epub PMID:22562503.

735. Ildefonso CJ, Bond WS, Altawashi AR, Hurwitz MY, Hurwitz RL. “The Liberation of CD44 Intracellular Domain Modulates Adenoviral Vector Transgene Expression.” J. Biol. Chem. 287, 32697-32707, 2012, PMID:22865879.

734. Hurwitz RL. “A New Vision of Mesenchymal Stem Cells.” Mol. Therapy 20:2017-2018, 2012. PMID:23131854.

733. Travis W. Hein, Yi Ren, Luke B. Potts, Zhaoxu Yuan, Enoch Kuo, Robert H. Rosa, Jr. and Lih Kuo “Acute Retinal Ischemia Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production.” IOVS January 2012, Vol. 53, No. 1, 30-36.

732. Luke B. Potts, Yi Ren, Guangrong Lu, Enoch Kuo, Ellen Hgo, Lih Kuo and Travis W. Hein “Constriction of Retinal Arterioles to Endothelin-1: Requisite Role of Rho Kinase Independent of Protein Kinase C and L-Type Calcium Channels.”  IOVS May 2012, Vol. 53, No. 6, 2904-2912.